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NCT Number: NCT07197892

Conversational AI Platform for Early Pregnancy Care City-wide Recruitment: A Feasibility Study

This study seeks to determine pregnant patients in the Philadelphia area can be recruited to a conversational AI texting platform. The trial will be considered feasible if recruitment goals are met in proportion to delivery volume at the hospital.

Recruiting

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Key information

Conditions

Early Pregnancy Abortion, Spontaneous Female Urogenital Diseases and Pregnancy Complications Pregnancy Complications Urogenital Diseases

Age range

15 year and older

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Penn Medicine

Philadelphia, Pennsylvania, 19104, United States

Location status: Recruiting

Location contact

Arden McAllister

CONTACT

[email protected]

267-785-8044

About this study

The investigators developed a conversational AI platform to improve periconception care (CIRCA) to engage individuals in their healthcare decision making, reduce barriers to care, and ultimately reduce widespread inequities in reproductive and maternal health.

CIRCA was developed to enable care from positive pregnancy test onward. After a positive test, patients scan a QR code to onboard via SMS to the program. A positive pregnancy test is confirmed, and an estimated gestational duration is calculated from last menstrual period, if known. If unknown, the patient is directed to schedule a visit at a nearby early pregnancy assessment center where they can receive routine testing and counseling to confirm the pregnancy and its gestational duration. They are then able to receive triage and scheduled educational content.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Willing and able to provide informed consent
  • Access to a working mobile phone
  • Ability to read English
  • Pregnant with a gestational age less than 12 weeks, 6 days by last menstrual period or by ultrasound, or per patient self-report

Exclusion criteria

N/A

Treatment and study plan

CIRCA Texting Platform

Other

Two-way texting platform that uses artificial intelligence to match patient texts to clinician-vetted responses and send educational content

Primary outcomes

  1. Feasibility of citywide recruitment of pregnant patients in Philadelphia.

    Time frame: 12 months

    Proportion of pregnant patients in Philadelphia who sign up to use CIRCA texting platform

Secondary outcomes

  1. Platform engagement

    Time frame: Between platform enrollment up until 12 weeks, 6 days gestation

    Percentage of surveys completed by participant

  2. Platform acceptability

    Time frame: To be completed at 1 week of use and at final study survey (up to 12 weeks 6 days gestation)

    Net promoter score (Range 0-10, with a higher score indicating a better rating)

  3. Birth outcome

    Time frame: From platform enrollment up until the event of a live birth or other pregnancy outcome.

    Early pregnancy loss, ectopic pregnancy, abortion, severe maternal morbidity, preterm birth

  4. Emergency Department Utilization

    Time frame: From platform enrollment until 12 weeks, 6 days gestation.

    Emergency Department visits

Study contacts

Contact information is provided by the study sponsor or research team.

Arden McAllister, MPH

CONTACT

[email protected]

267-785-8044

Sponsors and collaborators

Lead sponsor

University of Pennsylvania

Other

Registry information

Acronym: CIRCA

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
Sep 30, 2025
Registry last updated
Apr 23, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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