Controlled Ovarian Stimulation by HP-hMG for IVF / ICSI Cycles: Study on Ovarian Hyper Stimulation Syndrome in a Cohort of Women From 18 to 36 Years Old.

Inclusion criteria

• Women who present infertility of more than one year and are candidates for a first or second IVF cycle with or without ICSI for whom HP-hMG is prescribed for COS.
• Absence of infertility treatment during the last 3 months before enrolment.
• Age: from 18 to 36 years old.
• BMI between 18 and 30 kg / m².
• Presence of both ovaries accessible to puncture and absence of ovarian or uterine abnormalities.
• Male or female infertility.
• Ovarian stimulation by HP-hMG with pituitary desensitization by a GnRH agonist or antagonist.
• Normal ovarian reserve according to physician habitual evaluation.
• Consent to participate of the no-interventional study and signature of the patients' information sheet.

Exclusion criteria

• Presence of a chronic disease, cancer or endocrine disease that could potentially influence the results of the stimulation or that represents a contraindication for ovarian stimulation.
• Known endometriosis grade III or IV.
• Contraindication to the use of gonadotropins or current pregnancy diagnosed by the clinician.
• Recurrent miscarriages, known genetic disease of one of the partners or indication of a preimplantation genetic diagnosis (PGD).
• Smoking over than 10 cigarettes / day.´
• Participation in an interventional study at the time of inclusion.
• Known poor ovarian response in a previous cycle of stimulation (number of oocyte collected ≤ 3, and / or more than 2 previous IVF/ICSI cycles and / or abnormal result in ovarian reserve test (AMH < 1 ng/ml with Immunotech equipment or AMH<0.7 ng/ml with DSL equipment).