Control of MRSA in Nursing Homes: Decolonization vs Standard Precautions

The purpose of this study is to determine the better approach between the currently procedure (i.e. standards precautions) and a reinforced strategy to control MRSA transmission in the institutionalized population of nursing homes in Canton of Vaud, Switzerland.

Completed

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Key information

Conditions

Methicillin-Resistant Staphylococcus Aureus

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

About this study

MRSA carriage among nursing homes residents of Canton Vaud, Switzerland, is increasing, despite use of standard precautions. Recommendation to prevent MRSA transmission in long term care facilities are lacking. We aim to reinforce the current infection control strategy by general MRSA screening of institutionalised residents and decolonisation of MRSA carriers. Because the uncertainties in the impact of this reinforced strategy, we aim to compare this action to the policy actually applied.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

all nursing homes of canton Vaud, Switzerland, that give the consent of participation

Exclusion criteria

refusal to participate

Inclusion criteria

for decolonisation in intervention nursing homes:

all MRSA positive residents living in a Nursing Home included in the intervention group

Exclusion criteria

for decolonisation:

residents that refuse to be screened or refused the decolonisation
life expectancy shorter of 7 days
known intolerance of disinfectant/ topical antibiotics used in the protocol
active MRSA infection
asymptomatic MRSA bacteriuria
stage IV wound (according to National Pressure Ulcer Advisory Panel)

Treatment and study plan

Intervention

Other

5 days topical decolonisation including nasal mupirocin tid, chlorhexidine mouth wash tid, chlorhexidine body wash once daily.

Daily direct resident's environmental disinfection during decolonisation.

Other names: topical MRSA decolonisation and environmental disinfection

Primary outcomes

To determine the change in prevalence of MRSA carriage among residents of each Nursing homes group at the end of the one study year

Time frame: 1 year

in each control and intervention nursing home: MRSA screening of all residents of nursing homes of Canton Vaud, at baseline and 1 year later, in order to compare MRSA prevalence changes at nursing homes levels

Secondary outcomes

To determine the effectiveness of the reinforced strategy to prevent MRSA infection, compared to the standard strategy

Time frame: 1 year

In a subpopulation of all nursing homes residents (10% of the whole population), recording of all microbiologically documented MRSA infection, according to nosocomial infection definitions of the Center of Diseases Control (CDC) of Atlanta.

Sponsors and collaborators

Lead sponsor

University of Lausanne Hospitals

Other

Registry information

Official study title

Universal Screening and Decolonization vs Standard Precautions for Control of Methicillin-resistant Staphylococcus Aureus (MRSA) in Nursing Homes: a Cluster, Randomised Controlled Study.

Important dates

Study start: 2010
Primary completion: 2011
Study completion: 2011
First posted: Jun 7, 2010
Registry last updated: Mar 30, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed