Contributing Factors to Anterior Resection Syndrome and Its Impact on Quality of Life: A Retrospective Cohort Study

This study adds to the understanding of the contributing factors leading to LARS, the long term effects of this syndrome post-operatively and its impact on quality of life.

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Key information

Conditions

Low Anterior Resection Syndrome Cancer Colonic Diseases Digestive System Diseases Gastrointestinal Diseases Intestinal Diseases Neoplasms Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications Quality of Life Rectal Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Mater Dei Hospital

Valletta, Malta

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

All adult patients >18 years, under the care of all surgical firms at Mater Dei Hospital, who had undergone anterior resection for rectal cancer between January 2014 and December 2016

Exclusion criteria

colorectal cancer (>15cm) from anal verge
permanent stoma
known disseminated or recurrent disease,
patient without restitution of bowel continuity after 1 year

Treatment and study plan

anterior resection

Procedure

The distance from anal verge, preoperative radiotherapy and presence of stoma were analysed

Other names: radiotherapy +/- chemotherapy

Primary outcomes

LARS incidence

Time frame: 1 year

Incidence of LARS in patients who had anterior resection
Risk factors

Time frame: 1 year
Variable factors which might have contributed to LARS were the following:
- Age
- Gender
- Diabetes mellitus
- Pathological stage
- MRI stage
- Distance from anal verge
- Surgical technique
- Preoperative radiotherapy
- Preoperative chemotherapy
- Postoperative radio/chemotherapy
- Type of anastomosis
- Presence of stoma
- Interval from stoma reversal
- Duration of follow-up
Life

Time frame: 1 year

The association between LARS and quality of life was assessed.

Sponsors and collaborators

Lead sponsor

University of Malta

Other

Registry information

Important dates

Study start: 2018
Primary completion: 2019
Study completion: 2019
First posted: Oct 3, 2019
Registry last updated: Oct 3, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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