Contrast Ultrasound Perfusion Imaging in Peripheral Arterial Disease (PAD)

Contrast ultrasound is a technique that can quantify blood flow in the tissues of the body by ultrasound detection of microbubble contrast agents that behave in the circulation similar to red blood cells. In this study, the investigators hypothesize that contrast ultrasound of blood flow in the leg (thigh and calf) at rest and during stress produced by medications that mimic exercise (vasodilator stress) can provide information on the location and severity of peripheral vascular disease (blockages of the blood vessels in the leg). The investigators will also determine whether symptom improvement after revascularization (procedures to open up or bypass the blockages) is directly related to the improvement in blood flow.

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Key information

Conditions

Peripheral Arterial Disease Arterial Occlusive Diseases Arteriosclerosis Atherosclerosis Cardiovascular Diseases Peripheral Vascular Diseases Vascular Diseases

Age range

19 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Oregon Health & Science University

Portland, Oregon, 97239, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Known or suspected PAD
Lower extremity angiography or MRA planned or performed within 6 months

Exclusion criteria

Age <19 y.o.
Pregnant or lactating females
Hypersensitivity to ultrasound contrast agent, dipyridamole, or regadenoson
Severe reactive airways disease
Evidence right-to-left shunt (identified on screening echo)
NYHA Class III or IV heart failure.
Planned amputation
Unstable coronary artery disease or severe aortic stenosis

Treatment and study plan

Primary outcomes

Quantitation of Perfusion

Time frame: Immediate

Correlation of skeletal muscle perfusion with symptom status

Sponsors and collaborators

Lead sponsor

Oregon Health and Science University

Other

Registry information

Official study title

Contrast Ultrasound Perfusion Imaging in Peripheral Arterial Disease

Important dates

Study start: 2011
Primary completion: 2016
Study completion: 2016
First posted: Jun 21, 2011
Registry last updated: Sep 27, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed