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Completed

NCT Number: NCT03470454

Contrast Nephropathy in Type 2 Diabetes

To study the effect of radiocontrast material on kidney functions in diabetics with microalbuminuria

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Key information

Conditions

Kidney Function Affection Upon Exposure to Radiocontrast Diabetes Diabetes Mellitus Endocrine System Diseases Glucose Metabolism Disorders Metabolic Diseases Microalbuminuria Nutritional and Metabolic Diseases

Age range

21 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Faculty of medicine Fayoum univesity, Al Fayyum, Egypt

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About this study

Study design:

This study will be an observational prospective cohort study.

Study population:

Diabetics undergoing any intervention using radiocontrast material for any medical indication in Fayoum universiy hospital will be selected. There will be two arms of the study,each arm will contain 20 patients first arm diabetics on linagelptin, second arm diabetics on other DPP4 inhibitors.

Data collection:

Patients will be subjected to; full clinical examination,waist hip ratio assessment,BMI assessment fasting blood glucose,Serum uric acid, urine ACR, eGFR will be done before and after the investigation.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Diabetics on DPP 4 inhibitor treatment

Exclusion criteria

  • Diabetics on insulin

Treatment and study plan

Linagliptin Oral Tablet

Drug

Linagliptin for blood glucose control

Primary outcomes

  1. affection of estimated glomerular filtration rate

    Time frame: Two months

    A significant decrease in estimated glomerular filtration rate (eGFR)

Secondary outcomes

  1. change in serum uric acid

    Time frame: Two months

    A significant rise in serum uric acid

Other outcomes

  1. Affection of albumin creatinine ratio

    Time frame: Two months

    A significant increase in albumin creatinine ratio in urine (ACR)

Sponsors and collaborators

Lead sponsor

Fayoum University

Other

Collaborators

  • Boehringer Ingelheim

Registry information

Official study title

Prevalence of Contrast Nephropathy in Type 2 Diabetes Patients With Microalbuminuria

Acronym: VCG4

Important dates

Study start
2018
Primary completion
2018
Study completion
2018
First posted
Mar 20, 2018
Registry last updated
Sep 16, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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