Contralateral R1 in Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease affecting both upper and lower motor neurons. Electroneuromyography is an important tool for the diagnosis. Previous studies have shown that different components of the blink reflex, such as the latencies of homo- and contralateral R2 responses can be affected. Studies have found that a contralateral R1 component can appear in neurological diseases with affection of the central nervous system especially upper motor neuron, such as HTLV1 infection. Thus, you aim to determine if a contralateral R1 component could be present in ALS.

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Key information

Conditions

Amyotrophic Lateral Sclerosis Central Nervous System Diseases Metabolic Diseases Motor Neuron Disease Nervous System Diseases Neurodegenerative Diseases Neuromuscular Diseases Nutritional and Metabolic Diseases Proteostasis Deficiencies Spinal Cord Diseases TDP-43 Proteinopathies

Age range

18 year–99 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Hôpital neurologique Pierre Wertheimer, Bron, Rhone, France

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

For patients

Aged 18 to 99 years old
Referred for suspected motor neuromuscular disease
Collection of non-opposition

For healthy subjects:

Aged 18 to 99 years old
Absence of any neurological pathology
Collection of non-opposition

Exclusion criteria

Previous damage linked to another cause of the cranial nerves
Prior brainstem lesions
Persons deprived of liberty by a judicial or administrative decision
Patient under judicial protection, unable to express consent

Treatment and study plan

blink reflex evaluation

Diagnostic Test

A blink reflex evaluation will be performed in all subjects

Primary outcomes

Presence of a contralateral R1 component on blink reflex evaluation.

Time frame: Day 1

A blink reflex evaluation will be performed in all subjects : Blink reflex will be recorded with surface electrodes placed medially over the lower part of the eyelid, on the orbicularis oculi muscle, with a reference electrode 2 cm laterally. Stimuli will be delivered to the supraorbital nerve by surface electrodes with an intensity required to generate a consistent homolateral R1 response.

A contralateral R1 component will be defined as an early compound muscle action potential recorded in the contralateral orbicularis oculi muscle.

Sponsors and collaborators

Lead sponsor

Hospices Civils de Lyon

Other

Registry information

Official study title

Evaluation of Contralateral R1 Component of the Blink Reflex in Patients With Amyotrophic Lateral Sclerosis

Acronym: MOTOBLINK

Important dates

Study start: 2024
Primary completion: 2024
Study completion: 2024
First posted: Jan 16, 2024
Registry last updated: Oct 9, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

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