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Completed

NCT Number: NCT07425288

Contralateral Effects of Unilateral Isokinetic vs. Single-Leg Squat Training in Sedentary Women

This randomized controlled trial aims to investigate the contralateral effects of unilateral training in sedentary women. Specifically, the study compares unilateral isokinetic training and single-leg squat training to determine their effects on strength, proprioception, and muscle thickness in both the trained and untrained lower extremities.

Participants will be randomly assigned to one of the training groups. The intervention will be applied to one lower limb only. Strength, proprioception, and muscle thickness will be assessed before and after the intervention period. The primary objective is to evaluate whether unilateral training induces cross-education effects in the contralateral limb.

The findings of this study may contribute to rehabilitation strategies by clarifying the potential benefits of unilateral exercise programs for improving neuromuscular performance and muscle morphology in sedentary individuals.

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Key information

Conditions

Muscle Strength Proprioception

Age range

18 year–35 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Gazi University, Faculty of Health Sciences

Ankara, 06560, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • female gender,
  • no lower extremity problems in the last 6 months,
  • not actively participating in sports

Exclusion criteria

  • history of orthopedic surgery within the last 2 years,
  • ongoing lower extremity pain, systemic disease that could prevent exercise,
  • a neurological problems.

Treatment and study plan

Unilateral Isokinetic Training

Behavioral

Unilateral isokinetic strength training will be applied to one lower extremity using an isokinetic dynamometer. The training program will be performed according to the study protocol. The contralateral limb will not receive any direct intervention.

Unilateral Single-Leg Squat Training

Behavioral

Participants will perform unilateral single-leg squat exercises on one lower extremity according to the study protocol. The opposite limb will not receive any direct training.

Primary outcomes

  1. Muscle Strength

    Time frame: Baseline and after 6 weeks of intervention

    Muscle strength of the lower extremities will be assessed using isokinetic dynamometry to evaluate peak torque values in both the trained and contralateral limbs.

Secondary outcomes

  1. Proprioception

    Time frame: Baseline and after 6 weeks of intervention

    Lower extremity proprioception will be evaluated using joint position sense assessment to determine proprioceptive accuracy in both limbs.

  2. Muscle Thickness

    Time frame: Baseline and after 6 weeks of intervention

    Muscle thickness of selected thigh muscles will be measured using ultrasonography to assess morphological adaptations following unilateral training.

Sponsors and collaborators

Lead sponsor

Cagatay Muslum Gokdogan

Other

Registry information

Official study title

Contralateral Effects of Unilateral Isokinetic vs. Single-Leg Squat Training on Strength, Proprioception, and Muscle Thickness in Sedentary Women: A Randomized Controlled Trial

Important dates

Study start
2023
Primary completion
2024
Study completion
2024
First posted
Feb 20, 2026
Registry last updated
Feb 20, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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