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OpenTrials
Completed

NCT Number: NCT05496322

Continuous Vs Intermittent Non Invasive Blood Pressure Monitoring in Preventing Post Operative Organ Failure

Continuous non-invasive arterial pressure monitoring has the potential to decrease the duration of intraoperative hypotension and hypertension compared to conventional intermittent blood pressure monitoring. Chen et al. demonstrated using continuous non-invasive arterial pressure devices for every hour of surgery it is possible to identify an average of 14 minutes of potentially treatable hypotensive and hypertensive time(12). Whether the ability to detect more hypotension events by continuous non-invasive arterial pressure monitoring use can improve patient outcomes, is still an open research question

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Key information

Conditions

Blood Pressure Determination Hemodynamic Monitoring Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

A.O.U. G.Martino - University of Messina

Messina, 98100, Italy

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • All adult (age ≥18 years) patients scheduled for elective non-cardiac surgery in participating centers
  • Surgical case planned with non invasive blood pressure monitoring according to local clinical practice or policies.

Exclusion criteria

  • Missing of preoperative serum creatinine during 30 days prior surgery
  • Preoperative dialysis
  • Chronic kidney disease (eGFR < 60ml/min Cockcroft-Gault equation)
  • Surgical procedure lasting less than 60 min
  • Planned use of permissive hypotension
  • Urological procedures (including nephrectomy and renal transplantation)
  • Refusal to give informed consent

Treatment and study plan

Continuous Non Invasive Blood Pressure Monitoring

Device

Continuous non-invasive arterial pressure monitoring

Intermittent Non Invasive Blood Pressure Monitoring

Device

Intermittent non-invasive arterial pressure monitoring

Primary outcomes

  1. Post operative myocardial injury

    Time frame: 1 week

    The primary outcome will be the proportions of myocardial injury (Definitions: elevation of serum Troponin T (TnT) >= 30 ng/L in the first post-operative week)

Secondary outcomes

  1. Post operative Acute kidney injury

    Time frame: 1 week

    Proportions of postoperative AKI (Definition: increase in postoperative serum creatinine concentration during the first 7 postoperative days by more than 1.5-fold or greater than 0.3 mg/dl. Preoperative concentration was defined as the most recent recorded measurement within 30 days before the surgery)

  2. Post operative death

    Time frame: 28 day after surgery

    Death during postoperative hospital stay

  3. Events 30d post surgery

    Time frame: 30 days after surgery

    Any of the following events after surgery: Stroke, Non fatal cardiac arrest, AKI stage 2-3, Sepsis, Death)

  4. Events 90d post surgery

    Time frame: 90 days after surgery

    Any of the following events after surgery: Stroke, Non fatal cardiac arrest, AKI stage 2-3, Sepsis, Death)

Sponsors and collaborators

Lead sponsor

University of Messina

Other

Collaborators

  • Societa Italiana Anestesia Analgesia Rianimazione e Terapia Intensiva

Registry information

Acronym: NiMon

Important dates

Study start
2023
Primary completion
2025
Study completion
2025
First posted
Aug 11, 2022
Registry last updated
Mar 10, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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