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OpenTrials
Completed

NCT Number: NCT00569816

Continuous Versus Repetitive Sevoflurane Administration for Preconditioning

Pharmacologic preconditioning by volatile anesthetics may depend on the mode of administration. The researchers hypothesize that a continuous administration in patients scheduled for CABG surgery prebypass will be less effective in terms of attenuating myocardial cell damage compared to a repetitive administration with a double wash in/wash out schedule. A control group will receive propofol as their primary anesthetic.

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Key information

Conditions

Myocardial Injury

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

University Hospital Schleswig-Holstein, Campus Kiel

Kiel, 24105, Germany

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients schedulded to undergo CABG surgery
  • Age 18 to 80 years
  • Ejection fraction > 40%

Exclusion criteria

  • Emergency cases
  • Diabetes
  • Not able to give informed consent
  • Ejection fraction < 40%

Treatment and study plan

Sevoflurane

Drug

1 MAC Sevoflurane will be given either continuously after induction of anesthesia until initiation of cardiopulmonary bypass or will be repetitively washed in and out twice before initiation of cardiopulmonary bypass.

Primary outcomes

  1. Myocardial cell damage as assessed by plasma levels of Troponin T

    Time frame: from induction of anesthesia until hospital discharge

Secondary outcomes

  1. Length of stay on the ICU and in the hospital

    Time frame: from hospital admission until hospital discharge

Sponsors and collaborators

Lead sponsor

University Hospital Schleswig-Holstein

Other

Collaborators

  • Abbott
  • Department of Anaesthesiology and Intensive Care Medicine

Registry information

Official study title

A Comparison Between Continuous and Repetitive Sevoflurane Administration for Preconditioning During Coronary Artery Bypass Surgery

Important dates

Study start
2005
Study completion
2007
First posted
Dec 7, 2007
Registry last updated
Dec 7, 2007

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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