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Completed

NCT Number: NCT02879201

Continuous Venovenous Hemodiafiltration Versus Sustained Low-efficiency Hemodialysis for Critically Ill Patients With Acute Kidney Injury in Intensive Care Unit

The investigators conducted a comparison trial between SLED and CRRT in critically ill patients to evaluate the outcome for all cause mortality at 30 day . The secondary outcome were recovery of renal function, complications during therapy and duration of hospitalization.

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Key information

Conditions

Acute Kidney Injury Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Kidney Diseases Male Urogenital Diseases Renal Insufficiency Urogenital Diseases Urologic Diseases

Age range

18 year–90 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Renal Unit, BMA Medical College and Vajira Hospital

Bangkok, 10300, Thailand

About this study

The investigators performed a single center experience accumulated over 12 months since February 2009 with a continuous venovenous hemodiafiltration (CVVHDF) and hybrid technique named sustained low-efficiency dialysis (SLED). The primary end point was death from any cause by day 30. Intensive care unit (ICU) patients were eligible for inclusion when serum creatinine was > 2 mg/dL, and renal replacement therapy (RRT) was initiated. The selected patients were treated with CVVHDF or SLED.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • The inclusion criteria were
  • AKI requiring RRT
  • Hemodynamic instability defined by systolic blood pressure ≤ 90 mmHg and/or diastolic blood pressure ≤ 60 mmHg
  • Patients requiring initiation to vasopressor support

Exclusion criteria

  • Patients with pre-existing chronic kidney disease ( eGFR less than 30 mLmin/1.73m2) were excluded

Treatment and study plan

Slow efficiency dialysis

Procedure

Slow dialysis 4 times weekly 8 hours CVVHDF predilution mode

Other names: CRRT

Primary outcomes

  1. All-cause mortality

    Time frame: 30 day

    ll-cause mortality at 30 days following RRT initiation

Secondary outcomes

  1. Numbers of patients with abnormal laboratory values

    Time frame: 30 days

    Renal function impairment

  2. ICU stay

    Time frame: 30 days

    Total days in ICU

Other outcomes

  1. Adverse events during treatment

    Time frame: 30 days

    Number of patients with catheter infection

Sponsors and collaborators

Lead sponsor

Bangkok Metropolitan Administration Medical College and Vajira Hospital

Other Gov

Registry information

Important dates

Study start
2009
Primary completion
2009
Study completion
2016
First posted
Aug 25, 2016
Registry last updated
Sep 1, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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