Continuous Renal Replacement Therapy, Impact on Intensive Care Unit Length of Stay

This large national cohort study, including over 500,000 patients, where around 5% are treated with continuous renal replacement therapy (CRRT) , aims to evaluate the association between time to initiation of CRRT and intensive care unit (ICU) length of stay (LOS).

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Key information

Conditions

AKI - Acute Kidney Injury Acute Kidney Injury Critical Illness Disease Attributes Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Kidney Diseases Male Urogenital Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Renal Insufficiency Urogenital Diseases Urologic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

About this study

This large national cohort study, including over 500,000 patients, aims to evaluate the association between time to initiation of continuous renal replacement therapy (CRRT) and intensive care unit (ICU) length of stay (LOS).

The investigators hypothesize that earlier start of CRRT is associated with shorter length of stay among critically ill patients.

CRRT is seen as a costly intervention, and after studies failing to demonstrate a mortality benefit from earlier initiation, the trend is to push, or postpone the start of CRRT. In Sweden the additional cost of CRRT amounts to around 5000 SEK, approximately 500 dollars/euros per 24 hours. However, the 24-hour cost of staying in the ICU is around 58000 SEK or 5800 dollars/euros.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients with critical illness
Admitted to Swedish ICUs from 2010-2023
Adult (18 years or older)

Exclusion criteria

*Patients under 18 years of age

Treatment and study plan

continuous renal replacement therapy

Device

We are evaluting early vs late initiation of CRRT

Primary outcomes

Intensive care unit (ICU) length of stay (LOS) measured in hours

Time frame: ICU LOS during the study period, from admission to discharge, average 168 hours (one week)

Hours from baseline, i.e. ICU admission (time=0) to ICU discharge (time=0+hours in ICU)

Secondary outcomes

Mortality

Time frame: ONE-YEAR Mortality post admission

Days from baseline, i.e. ICU admission to 30, 90,180 and 365 day mortality
Mechanical ventilation

Time frame: Time on mechanical ventilation during the study period, average one week, but up to ICU discharge

Hours from baseline, i.e. start of ventilation (time=0) until end of ventilation, hours

Study contacts

Contact information is provided by the study sponsor or research team.

Max Bell, MD, PhD

CONTACT

[email protected]

+46708278533

Sponsors and collaborators

Lead sponsor

Karolinska Institutet

Other

Registry information

Official study title

CIILOS - Continuous Renal Replacement Therapy, Impact on Intensive Care Unit Length of Stay

Acronym: CIILOS

Important dates

Study start: 2026
Primary completion: 2026
Study completion: 2026
First posted: May 14, 2026
Registry last updated: May 20, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed