Continuation Study of the Oral AKT Inhibitor GSK2110183

Inclusion criteria

• Has provided signed informed consent for this study.
• Is currently participating in a GSK2110183 study (monotherapy or in combination with an approved anti-cancer agent) sponsored by GSK or by another research organization working on behalf of GSK.
• Currently benefitting from continued treatment and have an acceptable safety profile with GSK2110183 as determined by the investigator following previous treatment with GSK2110183 either as monotherapy or as part of a combination treatment regimen.
• Continued ability to swallow and retain orally administered study treatment(s) and does not have any clinically significant GI abnormalities that may alter absorption such as malabsorption syndrome or major resection of the stomach or bowels.
• Male subjects with a female partner of childbearing potential must be willing to continue practicing the same acceptable method of contraception as used in the parent study during the rollover study and for at least 16 weeks after the last dose of GSK2110183.
• Female subjects of childbearing potential, as defined in the parent study, must be willing to continue practicing the same acceptable method of contraception as used in the parent study during the rollover study and for at least 4 weeks after the last dose of GSK2110183.
• Female subjects of childbearing potential, as defined in parent study, must have negative serum pregnancy tests at the time of transition to this study.
• Maintain a performance status score of 0 to 2 according to the Eastern Cooperative Oncology Group (ECOG) scale
• Subjects with Type II diabetes are only allowed if their HbA1C is less than 8 percent at study entry.
• Have adequate organ system function

Exclusion criteria

• Permanent discontinuation of GSK2110183 in the parent study due to toxicity or disease progression.
• Concomitant use of any type of anti-cancer treatment other than studied in the parent protocol.
• Local access to commercially available GSK2110183.
• Current use of a prohibitive medication(s)
• Current use of anticoagulants
• Any unresolved toxicity greater than Grade 2 , except for alopecia, (National Cancer Institute-Common Toxicity Criteria for Adverse Events [NCI-CTCAE], version 4.0) from parent study treatment at the time of transition to this study.
• History of HIV infection.
• Peripheral neuropathy greater than Grade 1
• History of hepatitis B or C infection (subjects with evidence of cleared hepatitis B are permitted).
• Evidence of severe or uncontrolled systemic diseases (e.g., unstable, or uncompensated respiratory, hepatic, renal, metabolic or cardiac disease).
• QTcF interval greater than 500 msecs at the time of transition to this study.
• Other clinically significant ECG abnormalities including 2nd degree (Type II) or 3rd degree atrioventricular (AV) block.
• Evidence of current Class II, III, or IV heart failure as defined by the New York Heart Association [NYHA, 1994] functional classification system at the time of transition to this study.
• Symptomatic or untreated leptomeningeal, CNS or brain metastases or spinal cord compression at the time of transition to this study.
• Lactating female or female who becomes pregnant prior to transition to this study.
• Previously diagnosed diabetes mellitus Type I. Subjects with Type II diabetes are allowed if entry criteria are fulfilled
• Any serious and/or unstable pre-existing medical, psychiatric disorder or other conditions at the time of transition to this study that could interfere with subject's safety, obtaining informed consent or compliance to the study procedures, in the opinion of the investigator or GSK Medical Monitor.