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OpenTrials
Completed

NCT Number: NCT00738166

Content, Bioavailability and Health Effects of Trace Elements and Bioactive Components in Organic Agricultural Systems

Trace elements, bioactive secondary metabolites and vitamins are among the most important quality parameters in plants. Yet, very little information is available on their content, bioavailability and health effects of organically grown plant food products. The main objective of the project is to study the impact of different agricultural management practises relevant for organic farming on the ability of cereal and vegetable crops to absorb trace elements from the soil and to synthesise bioactive compounds (secondary metabolites, antioxidant vitamins and phytates) with health promoting effects. Field experiments with a rigidly controlled design will be implemented together with state-of-the-art analytical techniques allowing solid conclusions to be drawn on the variability and optimum levels of bioactive compounds. The multitude of analytical data from plant and soil samples will be analysed by multivariate statistical methods in order to reveal differences between the cultivation systems used. Finally, the relationship between bioavailability of the nutrients studied and the elemental fingerprint of plants will be extracted by the statistical methods.

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Key information

Conditions

Age range

18 year–45 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

IHE-LIFE

Frederiksberg, 1984, Denmark

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy adults aged 18-45 years
  • BMI 20-30 kg/m2
  • Non-vegetarian

Exclusion criteria

  • Physical activity > 10 h/week
  • Intake of dietary supplements
  • Regular use of drugs
  • Chronic diseases
  • Smoking
  • Excessive intake of alcohol

Treatment and study plan

Organic or conventional diet

Other

12 days on fully controlled organic 1 diet, organic 2 diet and conventional diet

Diet (organic or conventional)

Other

organic or conventional diet

Primary outcomes

  1. Bioavailability of trace elements and secondary metabolites

    Time frame: 3 x 12 days

Secondary outcomes

  1. Health factors

    Time frame: 3 x 12 days

Other outcomes

  1. miRNA

    Time frame: 1 year

Sponsors and collaborators

Lead sponsor

University of Copenhagen

Other

Registry information

Acronym: OrgTrace

Important dates

Study start
2007
Primary completion
2010
Study completion
2010
First posted
Aug 20, 2008
Registry last updated
Jul 29, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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