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NCT Number: NCT03631810

Contemporary Clinical Management Of Acute Pulmonary Embolism

Acute pulmonary embolism is a potentially life-threatening disease with short-term mortality ranges from less than 1% to more than 30% during the hospital stay. Recent guidelines recommend to tailor diagnosis hospitalization and acute treatment based on the estimated risk for short-term Death.

The assessment of the contemporary clinical management of patients with acute pulmonary embolism across different specialties would be of crucial value.

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Key information

Conditions

Acute Pulmonary Embolism

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Ospedale San Giovanni Di Dio - Uo Cardiologia E Utic, Agrigento, AG, Italy

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About this study

This is a prospective, non-interventional, multicenter study in patients with acute pulmonary embolism admitted to Cardiology, Emergency and Internal Medicine Departments in Italy.

The aim of the study is to assess contemporary management strategies in patients with acute pulmonary embolism in terms of diagnosis, risk stratification, hospitalization and treatment in Italy and assess

  • their association with in-hospital and 30-day mortality and
  • their adherence to current guidelines of the European Society of Cardiology (ESC).

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients with acute, symptomatic acute pulmonary embolism
  • Age ≥ 18 years
  • Informed consent

Exclusion criteria

  • refusal of informed consent
  • participation in controlled trials on the management of patients with acute pulmonary embolism

Treatment and study plan

Primary outcomes

  1. In-hospital death

    Time frame: 30 days

    In-hospital Death and Death at 30 days

Secondary outcomes

  1. All cause Mortality and clinical worsening

    Time frame: 30 days

    Death or clinical deterioration at 30 days from the diagnosis of pulmonary embolism

  2. Pulmonary embolism related mortality for and clinical worsening

    Time frame: 30 days

    Pulmonary embolism-related death or clinical deterioration at 30 days from the diagnosis of pulmonary embolismembolism

  3. Adherence to guidelines

    Time frame: 30 days

    Adherence to current guidelines on the management of acute pulmonary embolism released by the ESC regarding diagnosis, risk stratification and treatment

Sponsors and collaborators

Lead sponsor

Heart Care Foundation

Other

Collaborators

  • University Of Perugia

Registry information

Official study title

Contemporary Clinical Management Of Acute Pulmonary Embolism. The COPE Study

Acronym: COPE

Important dates

Study start
2018
Primary completion
2021
Study completion
2021
First posted
Aug 15, 2018
Registry last updated
Feb 25, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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