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OpenTrials
Completed

NCT Number: NCT03377530

Contamination of Bacillus Species Sepsis.

Bacillus species are ubiquitous gram-positive spore-forming organisms. They rarely cause disease in the immunocompetent and are more frequently isolated as a culture contaminant. However, Bacillus Species can cause severe systemic infections in immunocompromised patients including preterm infants.

The purpose of this study is to identify the risk factors of these infections.

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Key information

Conditions

Bacillus Cereus Infection

Age range

Up to 28 day

Sex eligibility

All sexes

Study type

Observational

Primary location

Hôpital NOVO

Cergy-Pontoise, 95300, France

About this study

Non-anthrax Bacillus Species bacteria can be responsible for food poisoning and local infections. Rarely, they lead to severe infections like blood stream infections and meningitis especially in immunocompromised patients like preterm infants.

Bacillus Cereus is the most common members of the genus Bacillus. Only few reports studied these systemic infections in premature neonates. In order to identify the risk factors for severe Bacillus Species infections, we studied retrospectively eleven cases of these infections in our NICU and reviewed series and report cases in literature.

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • cases of Bacillus Species sepsis
  • cases of Bacillus species meningitis
  • with significant change in clinical status
  • Bacillus Species is the only organism isolated

Exclusion criteria

  • Bacillus Species isolated with other organisms and Bacillus Species without clinical change were considered to be contaminants

Treatment and study plan

Ways to prevent these infections.

Diagnostic Test

The purpose of this database is to describe the pathogenicity of this germ, the incriminated modes of contamination.

The collaborators studied the factors of poor prognosis and propose ways to prevent these infections.

Primary outcomes

  1. Severe infection rate due to Bacillus Sp germ

    Time frame: Through study completion, an average of 1 year.

    The purpose of this database is to mesure the pathogenicity of this germ based on the severe infection rate

Secondary outcomes

  1. To collecte the incriminated modes of contamination.

    Time frame: Through study completion, an average of 1 year.

    The purpose of this database is to describe the incriminated modes of contamination.

Sponsors and collaborators

Lead sponsor

Hôpital NOVO

Other

Registry information

Acronym: BACILLUS

Important dates

Study start
2008
Primary completion
2016
Study completion
2016
First posted
Dec 19, 2017
Registry last updated
Jun 9, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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