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Completed

NCT Number: NCT06249646

Contained Hepatic Vascular Injuries Following Liver Trauma

Background: For thirty years, a major shift in the management of liver trauma has been seen. Contained hepatic vascular injuries (CHVI), including pseudo aneurysms and arteriovenous fistula, are often feared due to their risk of secondary bleeding. Nonetheless, knowledge of CHVI is scarce and no guidelines on their management have been set. The investigators aimed to validate the risk factors of CHVI, identify associated morbidities, and establish a management protocol.

Study Design: A retrospective study on 318 liver trauma from a level 1 trauma center over the last 15 years, comparing the presence or not of CHVI. Univarious and multivarious analyses were performed. A comparison of the management of CHVI was also performed.

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Key information

Conditions

Hepatic Injury Aneurysm, False Cardiovascular Diseases Liver Injury Pseudoaneurysm Vascular Diseases

Age range

15 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

CHU de Nice

Nice, Alpes Maritimes, 06000, France

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • presence of liver trauma
  • age above 15 years old
  • a full contrast abdominal CT

Exclusion criteria

none

Treatment and study plan

Primary outcomes

  1. Identification of a % of CHVI on the initial or the follow-up Chest-Thorax scans.

    Time frame: 6 months

    A junior and a senior radiologist reviewed all initial and follow-up CT scans, blinded from the diagnostic.

    Contained hepatic vascular injuries (CHVI) was defined as Hepatic Pseudoaneurysm (HPA) and/or arterio-venous fistula (AVF), under the American Association for Surgery of Trauma (AAST) organ injury scale (2018 revision) for liver trauma definition: a contained focal collection of vascular contrast which decreases in attenuation on delayed phase images on contrast-enhanced CT

Secondary outcomes

  1. Investigate the management of CHVI following liver trauma.

    Time frame: 6 months

    size in millimeters of pseudoaneurym conducting to angio-embolization

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Universitaire de Nice

Other

Registry information

Official study title

Contained Hepatic Vascular Injuries Following Liver Trauma: a Retrospective Monocentric Study and Review of the Literature

Important dates

Study start
2022
Primary completion
2022
Study completion
2023
First posted
Feb 8, 2024
Registry last updated
Feb 8, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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