Consumption of Probiotics on Salivary Bacteria Causing Dental Caries

Dental caries is a multifactorial disease effecting majority of the human population.One of the etiological factor causing dental caries is salivary mutans streptococci. Reducing the levels of this bacteria in the saliva can significantly reduce the incidence of dental caries. A non-invasive intervention, such as the administration of probiotics reduced the salivary mutans streptococci levels.

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Key information

Conditions

Dental Caries Stomatognathic Diseases Tooth Demineralization Tooth Diseases

Age range

20 year–25 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 2 / Phase 3

About this study

40 candidates were selected from a pre-determined group and were randomly assigned to two groups. Group A (n=20) was administered probiotic drink and Group B (n=20) was administered placebo for 14 consecutive days. Saliva was collected on day 1 and day 15 to compare the salivary mutans streptococci levels.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Decayed Missing Filled Surfaces less than or equal to 6
Brushes twice daily

Exclusion criteria

undergoing orthodontic treatment
topical fluoride therapy in the past 2 yrs
using sugar free gums

Treatment and study plan

Probiotic

Biological

Probiotic was administered for a period of 14 consecutive days. Saliva was collected on Day 1, before intervention and on Day 15, after intervention

Other names: bacillus coagulans

Placebo

Other

placebo was administered for a period of 14 consecutive days. Saliva was collected on Day 1, before intervention and on Day 15, after intervention

Primary outcomes

counts of streptococcus mutans after the consumption of probiotic

Time frame: 15 days

Human saliva was assessed for the counts of streptococcus mutans, one of the major etiological factor for dental caries

Sponsors and collaborators

Lead sponsor

Sharda University

Other

Registry information

Official study title

Evaluation of the Consumption of Probiotics on the Bacteria Causing Dental Caries: A Randomised Clinical Trial

Important dates

Study start: 2015
Primary completion: 2015
Study completion: 2015
First posted: Apr 27, 2016
Registry last updated: Apr 27, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed