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Completed

NCT Number: NCT06607354

Consuming Grass Finished Lamb Improves Blood Plasma ω-3 Fatty Acid Response Among Healthy Consumers.

This study will investigate the impact of consuming grass-finished lamb meat on blood omega-3 PUFAs and cardiovascular risk factors compared to concentrate-finished lamb meat. Healthy volunteers will consume three portions of lamb meat/week from a grass-finished meat treatment or a concentrate-finished meat treatment for four weeks. Blood samples will be taken at weeks zero and four. The primary outcome is to assess difference in change in omega-3 PUFA concentration in plasma and platelets between treatment groups. The secondary outcome is to assess between groups differences in change in cardiovascular disease risk factors including blood pressure, BMI and lipids among healthy individuals.

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Key information

Conditions

Healthy

Age range

18 year–64 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

School of Biological Sciences, Queen's University Belfast

Belfast, BT9 5DL, United Kingdom

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy male and female volunteers aged between 18-64 years old.

Exclusion criteria

  • Participants with a BMI of <18.5 km/m² and greater than >35 km/m².
  • Participants who take prescribed medication, including statins to reduce LDL cholesterol, and any form of dietary supplements (excluding vitamin D).
  • People who smoke.
  • Participants who consume more than two portions of fish per month.

Treatment and study plan

Grass fed lamb

Other

This study investigated the impact of consuming grass finished lamb on total blood plasma and blood plasma phospholipids (PL) FA and on cardiovascular risk factors, including heart rate, blood pressure (BP), HDL-cholesterol, LDL-cholesterol, and TAG cholesterol, in humans.

Primary outcomes

  1. Fatty acid (%) change in blood plasma between treatments

    Time frame: Week 0 and week 4

    Primary outcome is to assess the impact of consuming grass vs concentrate finished lamb on blood plasma response in healthy volunteers

  2. Fatty acid change (%) in blood plasma phospholipids between treatments

    Time frame: Week 0 and week 4

    Primary outcome is to assess the impact of consuming grass vs concentrate finished lamb on blood plasma phospholipid response in healthy volunteers

Secondary outcomes

  1. Change in weight (kg) in participants between treatments

    Time frame: Week 0 and week 4

    Secondary outcome is to assess the impact of consuming grass vs concentrate finished lamb on weight among healthy volunteers

  2. Change in Body Mass Index (BMI) in participants between treatments - calculated by dividing weight (kg) by height in meters squared

    Time frame: Week 0 and week 4

    Secondary outcome is to assess the impact of consuming grass vs concentrate finished lamb on weight and BMI response in healthy volunteers

  3. Cholesterol

    Time frame: Week 0 and week 4

    Secondary outcome is to assess the impact of consuming grass vs concentrate finished lamb on total cholesterol, LDL, HDL and TAG response in healthy volunteers

  4. Blood pressure (diastolic and systolic)

    Time frame: Week 0 and week 4

    Secondary outcome is to assess the impact of consuming grass vs concentrate finished lamb on blood pressure (diastolic and systolic) response in healthy volunteers

Sponsors and collaborators

Lead sponsor

Queen's University, Belfast

Other

Collaborators

  • Agri-Food and Biosciences Institute

Registry information

Official study title

The Effect of Consuming Grass Finished Lamb Meat on Omega-3 Blood Response Among Healthy Consumers

Important dates

Study start
2019
Primary completion
2019
Study completion
2019
First posted
Sep 23, 2024
Registry last updated
Sep 24, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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