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NCT Number: NCT07294274

Construction and Clinical Validation Study of a Prediction Model for Depression After Ischemic Stroke

Post-stroke depression (PSD) is the most common neuropsychiatric disorder after a stroke, with an incidence rate of 20% to 60%. PSD is not only associated with higher mortality rates, poorer recovery, more obvious cognitive impairments, greater economic burdens, and lower quality of life, but also brings additional medical expenses and care pressure to families. Society also needs to bear higher medical costs. Currently, the early diagnosis of PSD is difficult, which may lead to poor prognosis after stroke. This study aims to utilize machine learning technology to integrate multi-dimensional indicators of patients with ischemic stroke, establish a risk prediction model for PSD, and assist in early, accurate, and individualized assessment of PSD risk in clinical practice.

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Key information

Conditions

Post-stroke Depression

Sex eligibility

All sexes

Study type

Observational

Primary location

The First Affiliated Hospital of Chongqing Medical University

Chongqing, China

Location status: Recruiting

Location contact

Yanping Zhang

CONTACT

[email protected]

86+15223049366

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients with acute ischemic stroke;
  • Admission within 7 days of symptom onset;
  • The patient and/or the family members sign a written informed consent form.

Exclusion criteria

  • Confusion of consciousness,severe cognitive impairment, etc
  • Individuals with a history of depression, schizophrenia, bipolar disorder, etc;
  • Individuals unable to participate in neuropsychological examinations due to hearing im pairments, lack of coordination, or neurological deficits, including se vere aphasia.

Treatment and study plan

Group patients based on whether they have been diagnosed with PSD.

Diagnostic Test

Group patients based on whether they have been diagnosed with PSD.

Primary outcomes

  1. The number of post-stroke depression (PSD) that occurs 3 months after stroke

    Time frame: 3 months after stroke

Study contacts

Contact information is provided by the study sponsor or research team.

Yanping Zhang

CONTACT

[email protected]

86+15223049366

Sponsors and collaborators

Lead sponsor

Min Su

Other

Collaborators

  • Chongqing Traditional Chinese Medicine Hospital

Registry information

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Dec 19, 2025
Registry last updated
Feb 5, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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