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NCT Number: NCT05944146

Consistency of Carotid Doppler Blood Flow and Thermodilution Technique

Currently, the gold standard method to estimate CO is the thermodilution technique, pulmonary artery catheter (PAC) and PiCCO system included, however, the invasiveness and complexity of the thermodilution technique have limited their usefulness in many clinical scenarios. By measuring the carotid blood flow, continuous carotid doppler technique has been reported to noninvasively estimate cardiac output (CO) and other parameters related to cardiac contractility and fluid status in various cardiovascular disorders. However, to the best of our knowledge, few study has been reported to evaluate the consistency of this technique in cardiac surgery patients. The aim of this study is to evaluate the tracking ability of CO changes measured by continuous carotid doppler technique in cardiac surgery patients, use the thermodilution technique as the referenced.

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Key information

Conditions

Cardiac Surgery

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Zhongshan hospital Fudan University

Shanghai, Shanghai Municipality, 200040, China

Location status: Recruiting

Location contact

Guang-wei Hao

CONTACT

[email protected]

02164041990

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • adult cardiac surgery patients
  • with thermodilution technique monitoring
  • mechanical ventilation

Exclusion criteria

  • life threatening arrhythmia
  • severe valve regurgitation
  • left ventricular ejection fraction less than 30%
  • patients with mechanical circulatory support

Treatment and study plan

passive leg raising

Behavioral

transfer a patient from semi-recumbent position to supine position with a 45° leg lifting

Dobutamine

Drug

infusion dobutamine

Primary outcomes

  1. cardiac output by thermodilution method

    Time frame: 5 minutes after the patients was sedated

    measuring cardiac output using thermodilution method

  2. cardiac output by continuous carotid doppler blood flow

    Time frame: 5minutes after the patients was sedated

    measuring cardiac output using continuous carotid doppler blood flow

  3. cardiac output by thermodilution method

    Time frame: 2 minutes after passive leg raising

    measuring cardiac output using thermodilution method

  4. cardiac output by continuous carotid doppler blood flow

    Time frame: 2 minutes after passive leg raising

    measuring cardiac output using continuous carotid doppler blood flow

  5. cardiac output by thermodilution method

    Time frame: 15 minutes after termination of passive leg raising

    measuring cardiac output using thermodilution method

  6. cardiac output by continuous carotid doppler blood flow

    Time frame: 15 minutes after termination of passive leg raising

    measuring cardiac output using continuous carotid doppler blood flow

  7. cardiac output by thermodilution method

    Time frame: 30 minutes after dobutamine infusion

    measuring cardiac output using thermodilution method

  8. cardiac output by continuous carotid doppler blood flow

    Time frame: 30 minutes after dobutamine infusion

    measuring cardiac output using continuous carotid doppler blood flow

Study contacts

Contact information is provided by the study sponsor or research team.

Guang-wei Hao

CONTACT

[email protected]

02164041990

Guo-wei Tu

CONTACT

[email protected]

02164041990

Sponsors and collaborators

Lead sponsor

Shanghai Zhongshan Hospital

Other

Registry information

Official study title

The Consistency of Tracking Changes of Cardiac Output by Carotid Doppler Blood Flow and Thermodilution Technique in Cardiac Surgery Patients

Important dates

Study start
2023
Primary completion
2026
Study completion
2026
First posted
Jul 13, 2023
Registry last updated
Jul 13, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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