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NCT Number: NCT03346512

Considerations on the Transfusion Threshold in Cardiac Surgery

This is a retrospective observational study of the transfusion threshold in cardiac surgery.

There is controversy in the literature regarding the transfusion threshold to be adopted, especially in a patient who has undergone cardiac surgery. Some authors suggest that the transfusion should be done in a restrictive way when a certain threshold in hemoglobin is reached, in order to avoid the risks it implies, especially infectious.This threshold is very controversial and remains to be defined (variations in the literature from 7g / dL to 9g / dL). Other authors conclude that there is no superiority of a restrictive transfusion compared to a more liberal transfusion, with regard to the morbidity or medical costs.

It is therefore interesting to study, in a retrospective manner, the global and multidisciplinary management of patients who have undergone a cardiac surgery within the CHU Brugmann hospital, to analyze if they have been adequately transfused.

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Key information

Conditions

Cardiac Surgery

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

CHU Brugmann

Brussels, 1020, Belgium

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients having undergone cardiac surgery (other than the placement of a pacemaker or defibrillator) within the CHU Brugmann hospital between 2006 and 2015

Exclusion criteria

  • N/A

Treatment and study plan

cardiac surgery

Procedure

Cardiac surgery

Primary outcomes

  1. Hemoglobin rate

    Time frame: Baseline (just before cardiac surgery)

    Hemoglobin rate

  2. Hemoglobin rate

    Time frame: One day after surgery (J1)

    Hemoglobin rate

  3. Hemoglobin rate

    Time frame: Two days after surgery (J2)

    Hemoglobin rate

  4. Hemoglobin rate

    Time frame: Five days after surgery (J5)

    Hemoglobin rate

  5. Hematocrit rate

    Time frame: Baseline (just before cardiac surgery)

    Hematocrit rate

  6. Hematocrit rate

    Time frame: One day after surgery (J1)

    Hematocrit rate

  7. Hematocrit rate

    Time frame: Two days after surgery (J2)

    Hematocrit rate

  8. Hematocrit rate

    Time frame: Five days after surgery (J5)

    Hematocrit rate

  9. International Normalized Ratio (INR)

    Time frame: Baseline (just before cardiac surgery)

    Coagulation indicator

  10. International Normalized Ratio (INR)

    Time frame: One day after surgery (J1)

    Coagulation indicator

  11. International Normalized Ratio (INR)

    Time frame: Two days after surgery (J2)

    Coagulation indicator

  12. International Normalized Ratio (INR)

    Time frame: Five days after surgery (J5)

    Coagulation indicator

  13. Creatinin rate

    Time frame: Baseline (just before cardiac surgery)

    Renal function indicator

  14. Creatinin rate

    Time frame: One day after surgery (J1)

    Renal function indicator

  15. Creatinin rate

    Time frame: Two days after surgery (J2)

    Renal function indicator

  16. Creatinin rate

    Time frame: Five days after surgery (J5)

    Renal function indicator

  17. Total amount of blood perfusions

    Time frame: Five days after surgery (J5)

    Total amount of blood perfusions

  18. Liquid balance

    Time frame: One day after surgery

    Ratio between total fluid intake (perfusion) and loss (blood and urine)

Sponsors and collaborators

Lead sponsor

Pierre Wauthy

Other

Registry information

Important dates

Study start
2016
Primary completion
2016
Study completion
2016
First posted
Nov 17, 2017
Registry last updated
Apr 19, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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