Consciousness-specific Brain Network Connection of Propofol Sedation and Prolonged Disorders of Consciousness

Inclusion criteria

• Age 18 - 65 years old, native Chinese speaker, dextromanuality;
• Chronic disorder of consciousness;
• Spinal cord electrical stimulator implantation under general anesthesia;
• Signed informed consent.

Exclusion criteria

• Continuous sedation was administered within 72 hours prior to the study;
• Open head injury, parenchymatectomy and other damage of brain structural integrity;
• The intracranial compliance decreased due to hydrocephalus and swelling;
• Known hearing impairment;
• Airway stenosis and various causes of severe ventilation or ventilation dysfunction;
• Known or suspected cardiac dysfunction;
• Allergic to intravenous general anesthetics;
• Associated with other mental or neurological diseases;
• Other reasons are not suitable to participate in this study.