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Completed

NCT Number: NCT02529046

Conjugated Linoleic Acid in Obese Women

In this trial, the investigators analyzed the effects of eight weeks of CLA supplementation associated with aerobic exercise on body fat and lipid profile in obese women.

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Key information

Conditions

Lipid Metabolism Disorders Body Weight Metabolic Diseases Nutrition Disorders Nutritional and Metabolic Diseases Obesity Overnutrition Overweight Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year–35 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Universidade Estadual de Londrina

Londrina, Paraná, 86.057-970, Brazil

About this study

The aim of this investigation was to analyze the effects of eight weeks of CLA supplementation associated with aerobic exercise on body fat and lipid profile in obese women. The investigators performed a randomized, double-blinded and placebo-controlled trial with 28 obese women who received 3.2 g/d of CLA or 4 g/d of olive oil (placebo group) while performing an 8-week protocol of aerobic exercise. Dietary intake (food record), body fat (DXA) and biochemical analysis (blood sample) were assessed before and after the intervention period.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Had no signs or symptoms of disease
  • No orthopedic injuries
  • Must be inactive or moderately active (defined as performing any type of physical exercise less than twice a week)
  • Must be non-smokers
  • Must be free from the use of ergogenic aids
  • Had no metabolic disorders or chronic degenerative diseases
  • Not use drug therapy for body mass loss.

Exclusion criteria

  • Had frequency to training sessions below 85% of the total sessions

Treatment and study plan

CLA

Dietary Supplement

CLA group received supplementation at a dose of 3.2 g/day (mixture of isomers of CLA isomers predominantly c9, t11 - 50% and c12, t10 - 80%). Aerobic exercise associated with CLA

Placebo

Behavioral

Placebo group received 4 g/day of olive oil. Aerobic exercise

Primary outcomes

  1. Body fat

    Time frame: 8 weeks

    Dual-energy X-ray absorptiometry

Secondary outcomes

  1. Total cholesterol

    Time frame: 8 weeks

    Blood analysis

  2. Triglycerides

    Time frame: 8 weeks

    Blood analysis

  3. High-density lipoprotein

    Time frame: 8 weeks

    Blood analysis

  4. Low-density lipoprotein

    Time frame: 8 weeks

    Estimated by Friedewald formula

  5. Trunk fat

    Time frame: 8 weeks

    Dual-energy X-ray absorptiometry

  6. Arm fat

    Time frame: 8 weeks

    Dual-energy X-ray absorptiometry

  7. Leg fat

    Time frame: 8 weeks

    Dual-energy X-ray absorptiometry

Other outcomes

  1. Body mass

    Time frame: 8 weeks

    Urano, model PS 180

  2. Maximum oxygen uptake

    Time frame: 8 weeks

    incremental treadmill test

Sponsors and collaborators

Lead sponsor

Universidade Estadual de Londrina

Other

Registry information

Official study title

Effect of Conjugated Linoleic Acid Associated With Aerobic Exercise on Body Fat and Lipid Profile in Obese Women: A Randomized, Double-blinded and Placebo-controlled Trial

Acronym: CLA

Important dates

Study start
2007
Primary completion
2007
Study completion
2007
First posted
Aug 19, 2015
Registry last updated
Aug 19, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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