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Completed

NCT Number: NCT03237650

Conditioned Pain Modulation Using Painful Cutaneous Electrical Stimulation or Simply Habituation?

Painful cutaneous electrical stimulation (PCES) and corresponding evoked potentials led to a significant pain relief and decrease of evoked potentials and has been used to analyze conditioned pain modulation (CPM). However, it is unknown whether the pain relief results from habituation to the repeated painful electric stimulation. We compared the effects of CPM and habituation on PCES-induced pain and PCES-evoked potentials and analyzed whether increased attention by a random change of electric intensities amplifies the habituation effects.

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Key information

Conditions

Habituation Chemically-Induced Disorders Mental Disorders Substance-Related Disorders

Age range

20 year–35 year

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • healthy volunteers

Exclusion criteria

  • any kind of disease

Treatment and study plan

Primary outcomes

  1. pain relief

    Time frame: during the measurement

    pain intensity of painful cutaneous electrical stimulation on a numeric rating scale (NRS 0-100)

  2. N1P1-amplitude

    Time frame: during the measurement

    Amplitudes of painful cutaneous electrical stimulation evoked potentials in µV

Secondary outcomes

  1. N1-latency

    Time frame: during the measurement

    Latency of the peak N1 of painful cutaneous electrical stimulation evoked potentials in msec

  2. P0N1-amplitude

    Time frame: during the measurement

    Amplitudes of painful cutaneous electrical stimulation evoked potentials in µV

Sponsors and collaborators

Lead sponsor

Ruhr University of Bochum

Other

Registry information

Important dates

Study start
2016
Primary completion
2016
Study completion
2016
First posted
Aug 2, 2017
Registry last updated
Aug 2, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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