Concentration/Meditation Limits Inflammation

Inclusion criteria

• Age ≥18 and ≤35 yrs
• Male
• Healthy
• Travel insurance (for travel to Poland for the training in the concentration/meditation technique)

Exclusion criteria

• Use of any medication
• Smoking
• Use of recreational drugs within 21 days prior to endotoxemia experiment day
• Use of caffeine or alcohol within 1 day prior to endotoxemia experiment day
• Previous participation in a trial where LPS was administered
• Surgery or trauma with significant blood loss or blood donation within 3 months prior to endotoxemia experiment day
• Participation in another clinical trial within 3 months prior to endotoxemia experiment day.
• History, signs, or symptoms of cardiovascular disease
• History of frequent vaso-vagal collapse or of orthostatic hypotension
• History of atrial or ventricular arrhythmia
• Hypertension (RR systolic >160 or RR diastolic >90)
• Hypotension (RR systolic <100 or RR diastolic <50)
• Conduction abnormalities on the ECG consisting of a 1st degree atrioventricular block or a complex bundle branch block
• Renal impairment: plasma creatinine >120 µmol/L
• Liver function abnormality: alkaline phosphatase>230 U/L and/or ALT>90 U/L
• History of asthma
• Obvious disease associated with immune deficiency.
• CRP > 20 mg/L, WBC > 12x109/L, or clinically significant acute illness, including infections, within 4 weeks before endotoxemia day