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Completed

NCT Number: NCT01121627

Computer-based Cognitive Training for Parkinson Disease

Parkinson's Disease (PD) is a neurodegenerative, progressive illness. It is a multi-system disease that influences not only the motor but also the cognitive and autonomic systems. The main cognitive impairment in individuals with PD is found in executive function (EF). EF is defined as a set of cognitive skills necessary for planning, monitoring and executing sequences of complex activities.

The primary study hypothesis is that computer-based training aimed at improving executive function will have a beneficial effect on gait functions.

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Key information

Conditions

Parkinson Disease Basal Ganglia Diseases Brain Diseases Central Nervous System Diseases Gait Movement Disorders Nervous System Diseases Neurodegenerative Diseases Parkinsonian Disorders Synucleinopathies

Age range

50 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Clalit Health Services, Haifa and Western Galilee District

Haifa, Israel

About this study

Parkinson Disease (PD) is a neurodegenerative, progressive illness. It is a multi-system disease that influences not only the motor but also the cognitive and autonomic systems. The main cognitive impairment in individuals with PD is found in executive function (EF). EF is defined as a set of cognitive skills necessary for planning, monitoring and executing sequences of complex activities. Previous studies have revealed some relation between cognitive states and physical functions in healthy adults. Few studies have examined the effect of computer-based cognitive training on various populations. These studies showed a positive emotional-cognitive effect in those populations. This type of intervention plan was also applied to PD patients. However, there are no reports on the effect of intentional cognitive training on gait functions. The purpose of the study is to assess whether cognitive training, designed to improve EF ability, can also improve gait function in PD patients.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Idiopathic PD.
  • Aged 50-80, living in north region of Israel.
  • Receive regular medications for PD.
  • Not suffering from irregular cognitive disturbance or MMSE<25.
  • Measured 1-3 on the Hoehn & Yahr scale.
  • Have access to a computer and the ability to operate it.

Exclusion criteria

  • Brain operation, including DBS transplant.
  • History of orthopedic problems that can impair gait (hip/knee fractures and back problems).
  • Orthopedic operation on lower limbs performed no later than six months prior to the beginning of the study.
  • Unbalanced general health: uncontrolled diabetes or blood pressure, etc.
  • Inability to walk independently.
  • Immunodeficiency diseases, active cancer, ischemic diseases.
  • Vision impairment, partial/full blindness.
  • Having participated in similar research or cognitive assessment during the previous year.
  • Have received cognitive or gait training under physical therapy or other programs.

Treatment and study plan

Computerized cognitive training

Other

A 12 week computerized cognitive training at home with the Attengo™ software program.

Primary outcomes

  1. Gait Function

    Time frame: 18 weeks

    At enrollment eligible individuals will undergo a thorough baseline assessment using a predefined set of tests and performance measurements. Within a week after enrollment each individual will receive guided training on the use of the intervention tool, the Attengo™ software program. Thereafter they will train at their homes, at least three times a week, for a period of 12 weeks. Follow up assessments will be performed within a week of the end of the training period and 4 weeks thereafter to check for long-term cognitive and motor changes.

Secondary outcomes

  1. Executive function

    Time frame: 18 weeks

    At enrollment eligible individuals will undergo a thorough baseline assessment using a predefined set of tests and performance measurements. Within a week after enrollment each individual will receive guided training on the use of the intervention tool, the Attengo™ software program. Thereafter they will train at their homes, at least three times a week, for a period of 12 weeks. Follow up assessments will be performed within a week of the end of the training period and 4 weeks thereafter to check for long-term cognitive and motor changes.

  2. Quality of life.

    Time frame: 18 weeks

    At enrollment eligible individuals will undergo a thorough baseline assessment using a predefined set of tests and performance measurements. Within a week after enrollment each individual will receive guided training on the use of the intervention tool, the Attengo™ software program. Thereafter they will train at their homes, at least three times a week, for a period of 12 weeks. Follow up assessments will be performed within a week of the end of the training period and 4 weeks thereafter to check for long-run cognitive and motor changes.

Sponsors and collaborators

Lead sponsor

Clalit Health Services

Other

Collaborators

  • Tel-Aviv Sourasky Medical Center

Registry information

Official study title

Effects of Computer-based Cognitive Training on Gait Function in Individuals With Parkinson Disease

Important dates

Study start
2010
Primary completion
2012
Study completion
2012
First posted
May 12, 2010
Registry last updated
Aug 24, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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