Computed Tomography Coronary Angiography (CTCA) and Coronary Flow in Stenosis Analysis

The investigators' rationale was to evaluate whether a 64-slice CT scanner allows accurate measurement of computed tomographic changes in coronary artery flow profiles and whether CT flow measurements are suitable for classifying the significance and hemodynamic relevance of a stenosis and thereby supplement as a functional parameter for morphological stenosis analysis.

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Key information

Conditions

Coronary Artery Disease Arterial Occlusive Diseases Arteriosclerosis Cardiovascular Diseases Constriction, Pathologic Coronary Disease Heart Diseases Myocardial Ischemia Pathological Conditions, Anatomical Pathological Conditions, Signs and Symptoms Vascular Diseases

Age range

51 year and older

Sex eligibility

All sexes

Study type

Observational

About this study

A total of 50 patients prospectively underwent computed tomography coronary angiography (CTCA) in a multidetector CT scanner (Brilliance 64, Philips) ± 1 day before or after invasive coronary angiography (ICA). Immediately thereafter, 2 radiologists reviewed the imaging data to detect any vessel segments with morphology poorly evaluable by CTCA. A locally constant cyclical measurement was acquired in these coronary arteries in breath-hold technique during the passage of a 50ml bolus of contrast media. For analysis, time-density curves of the bolus passage were registered in the coronary artery and the aorta (internal reference), the up-slopes were determined and correlated with each other. The results were compared with the ICA findings.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Clinically known or presumed CAD
Age > 50 years
Hospitalization for invasive coronary angiography
Sinus rhythm
Written informed consent by the patient to participate in the study after comprehensive presentation of the facts

Exclusion criteria

Age <= 50 years
Contraindications to contrast media administration (medical history of iodine allergy, nephropathy, latent or manifest hyperthyroidism)
Arrhythmias
Dyspnea at rest, acute unstable angina pectoris, acute myocardial infarction
Pregnancy
Implanted pacemaker
Unwillingness of patient to consent to the study

Sponsors and collaborators

Lead sponsor

University of Cologne

Other

Collaborators

Dept. of Radiology

Registry information

Official study title

CT Coronary Angiography: Coronary Flow Quantification Supplements Morphological Stenosis Analysis

Important dates

Study start: 2007
Primary completion: 2008
Study completion: 2008
First posted: Jun 16, 2009
Registry last updated: Jun 16, 2009

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed