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OpenTrials
Completed

NCT Number: NCT06701773

Computational Fluid Dynamics Predicting Intraprosthetic Thrombus Formation and Progression Following EVAR

Intraprosthetic thrombus (IPT) formation and its progression to limb graft occlusion (LGO) are significant complications following endovascular aneurysm repair (EVAR). Morphological metrics based on preoperative CTA have limited predictive value for these complications. This study aims to assess the potential of computational fluid dynamics (CFD) in predicting IPT formation and its progression to LGO after EVAR.

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Key information

Conditions

Intraprosthetic Thrombus Limb Graft Occlusion

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Aged 18 and above;
  • Patients undergone endovascular aneurysm repair;
  • Signed informed consent forms, willing to receive treatments.

Exclusion criteria

  • inflammatory aortic aneurysm;
  • patients diagnosed with connective tissue diseases;
  • patients diagnosed with atrial fibrillation;
  • patients lacking post-operative CTA;
  • Patients who are participating in other clinical projects;
  • Patients are not suitable to participate in this study.

Treatment and study plan

Primary outcomes

  1. Degree of intraprosthetic thrombus in limb graft

    Time frame: From January 2014 to June 2024

    Evaluate the area of thrombus occupying the lumen using postoperative CTA

Secondary outcomes

  1. Disease-related complications

    Time frame: From January 2014 to June 2024

    Disease-related complications associated with intraprosthetic thrombus or limb graft occlusion, such as thromboembolic events

Sponsors and collaborators

Lead sponsor

Xiangya Hospital of Central South University

Other

Collaborators

  • Second Affiliated Hospital of Nanchang University

Registry information

Official study title

Computational Fluid Dynamics Predicting Intraprosthetic Thrombus Formation and Progression Following Endovascular Aortic Repair: a Two-center Retrospective Study

Important dates

Study start
2014
Primary completion
2024
Study completion
2024
First posted
Nov 22, 2024
Registry last updated
Nov 22, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.