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OpenTrials
Enrolling by Invitation

NCT Number: NCT06964152

Computational Cardiac Imaging Analysis to Guide Ventricular Tachycardia Ablation Procedures (AI-VT)

The purpose of this study is to evaluate the clinical outcomes (clinical efficacy and safety) of using supplemental non-invasive computational ECG and cardiac imaging analysis tools to help guide ablation of ventricular tachycardia.

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Key information

Conditions

Ventricular Tachycardia (VT) Arrhythmias, Cardiac Cardiac Complexes, Premature Cardiac Conduction System Disease Cardiovascular Diseases Heart Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Premature Ventricular Contraction (PVC) Tachycardia Tachycardia, Ventricular Ventricular Fibrillation Ventricular Premature Complexes

Age range

21 year–90 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

UC San Diego Health

La Jolla, California, 92037, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age between 21 and 100
  • Evidence of ventricular tachycardia on ECG, telemetry or by CIED interrogation.

Exclusion criteria

Treatment and study plan

Computational electrocardiography and cardiac computed tomography mapping

Diagnostic Test

Use of non-invasive computational ECG and cardiac CT models to localize arrhythmia origins

Primary outcomes

  1. Recurrent ventricular tachycardia

    Time frame: 1 year

    Ventricular tachycardia episodes defined as implantable cardioverter defibrillator (ICD) therapies (anti-tachycardia pacing and shocks)

  2. All-cause death

    Time frame: 1 year

Secondary outcomes

  1. Acute hemodynamic decompensation

    Time frame: 24 hours post-op

    acute development of hypotension, cardiogenic shock, escalation of inotropes/pressors, or need for unplanned percutaneous hemodynamic support

  2. Unplanned prolonged ICU upgrade

    Time frame: 48 hours

    In outpatient elective cases, change in patient condiction neccessitating unplanned ICU upgrade lasting longer than 48 hours.

  3. acute cerebrovascular accident (embolic)

    Time frame: 24 hours post-op

  4. acute pericardial tamponade requiring intervention

    Time frame: 24 hours post-op

    new expanding hemorrhagic pericardial effusion causing tamponade requiring urgent pericardiocentesis

  5. vascular complication requiring intervention

    Time frame: 24 hours post-op

    vascular access complication (bleeding or occlusion) requiring blood transfusion or vascular procedure (such as peripheral angioplasty)

Sponsors and collaborators

Lead sponsor

University of California, San Diego

Other

Registry information

Official study title

Prospective Use of Computational Cardiac Imaging Analysis to Guide Ventricular Tachycardia Ablation Procedures (AI-VT)

Acronym: AI-VT

Important dates

Study start
2024
Primary completion
2029
Study completion
2034
First posted
May 9, 2025
Registry last updated
May 9, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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