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NCT Number: NCT04917328

Compression Ultrasonography in Non-high Probability of Deep Vein Thrombosis

Compression ultrasound is commonly used in emergency department. Accuracy to rule out deep vein thrombosis is excellent but lower then Ddimer assessment which is actually gold standard. With progress in formation of emergency physicians (EP), quality of material used, the investigators hypothesize that compression ultrasound can rule out deep vein thrombosis in case of non high probability, as standard care and DDimer assay.

Recruiting

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Key information

Conditions

Deep Vein Thrombosis Cardiovascular Diseases Embolism and Thrombosis Thrombosis Vascular Diseases Venous Thrombosis

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • adult patient
  • Patient presenting to the emergency department with clinical suspicion of DVT (i.e. pain and/or lower extremity edema).
  • Patient with a non-high probability according to the modified Wells score, i.e. a score of 0 or 1
  • Subject with a social health insurance plan
  • Subject able to understand the objectives and risks of the research and to give a signed and dated informed consent

Exclusion criteria

  • Patient with suspected pulmonary embolism
  • Patient with a high probability of DVT
  • Impossible to perform a whole leg doppler ultrasound within 5 days
  • Pregnant or breast-feeding woman, on patient's declaration
  • Subject under court protection
  • Subject under guardianship or curatorship

Treatment and study plan

compression ultrasound

Other

performing a compression ultrasound

Primary outcomes

  1. Negative predictive value of compression ultrasound for diagnosis of deep vein thrombosis

    Time frame: The measurement is assessed during ED stay or in 5 days if DD is positive with no DVT in compression ultrasound

Study contacts

Contact information is provided by the study sponsor or research team.

Mathieu OBERLIN, MD

CONTACT

[email protected]

03.88.12.79.85

Pierrick LE BORGNE, MD

CONTACT

[email protected]

03.88.12.86.90

Sponsors and collaborators

Lead sponsor

University Hospital, Strasbourg, France

Other

Registry information

Official study title

Evaluation of the Predictive Value of Compression Venous Ultrasound by the Emergency Physician for Excluding the Diagnosis of Proximal Deep Vein Thrombosis (DVT) in Patients With Non-high Clinical Pretest Probability

Acronym: EPREVUP

Important dates

Study start
2022
Primary completion
2027
Study completion
2027
First posted
Jun 8, 2021
Registry last updated
Aug 3, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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