Compound Adapalene and Clindamycin Hydrochloride Gel in Treatment of Patients With Acne

Inclusion criteria

• Age from 18 to 40 years old, female or male;
• Class I-III of Acne vulgaris according to the International Modified PILLSBURY Classification;
• Patients voluntarily take part in the study and sign the ICF.

Exclusion criteria

• The subject is known to be allergic to adapalene, clindamycin hydrochloride, clindamycin, and / or any components of gel excipient;
• Patients with secondary acne including occupational acne and corticosteroid-induced acne;
• The affected skin has other concomitant lesion (such as solar dermatitis, psoriasis, seborrheic dermatitis, eczema and extremely severe acne) which may impact the efficacy evaluation;
• Subject has the history of regional enteritis, ulcerative colitis or antibiotic-associated colitis;
• Patient has history of severe cardiac disease and hypertension;
• Patient has severe liver and kidney diseases with AST/ALT more than twice upper limitation, or Cr, total cholesterol and triglycerides above normal range;
• Patients with severe endocrine diseases, blood diseases, and neuropsychiatric disorders;
• Patients are known to have severe immune dysfunction, or need long-term use of corticosteroids or immunosuppressive agents;
• Pregnant or breastfeeding women, or unwilling to take effective contraceptive measures during the study;
• Alcoholic patients or drug abusers;
• Patient has used other acne drugs topically within 2 weeks before the study start;
• Patient has been administered with victoria A acid, vitamins, and antibiotics within 4 weeks before the study start;
• Patient has participated in other study within 3 months before the study start;
• The subject is not fit to take part in this study in the judgment of the investigator.