Composite Ratios Boost CRP's Power in Monitoring Ulcerative Colitis.

Inflammatory Bowel Disease (IBD) is a chronic, recurrent condition marked by disturbed levels of various hematological inflammatory cells and a deregulated immune environment. While C-reactive protein (CRP) is a key acute-phase reactant, its high levels can persist even after inflammation subsides. Other simple, cost-effective ratios, such as the Neutrophil-to-Lymphocyte Ratio (NLR), the Platelet-to-Lymphocyte Ratio (PLR), and Albumin-related ratios, also serve as promising, reproducible markers of systemic inflammation reflecting both immune status and nutrition. This study's objective is to evaluate the diagnostic performance of these various hematological inflammatory cellular components and CRP-related ratios (like the CAR) as predictors for Ulcerative Colitis (UC) disease severity, using colonoscopic and microscopic findings as the gold standard for comparison.

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Key information

Conditions

Ulcerative Colitis Colitis Colitis, Ulcerative Colonic Diseases Digestive System Diseases Gastroenteritis Gastrointestinal Diseases Inflammatory Bowel Diseases Intestinal Diseases

Age range

18 year–45 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Alexandria Faculty of medicine

Alexandria, El Alexandria, 21512, Egypt

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients who fulfilled the diagnostic criteria for UC;
Patients were free of exclusion criteria;
Patients who signed the written consent were enrolled in the study

Exclusion criteria

Patients who was Previously diagnosed with IBD or IBS;
Patients with recurrence of manifestations after surgical resection;
Patients who refused to sign the participation consent.

Treatment and study plan

C-Reactive Protein measuring CRP

Diagnostic Test

5-ml peripheral blood samples were aseptically obtained for a complete blood count, and ELISA estimation of serum CRP

CRP to Albumin Ratio

Diagnostic Test

Serum CRP to albumin ratio (CAR) is a combination of markers for systemic inflammation and nutritional status

Primary outcomes

The Correlation Between Clinical and Endoscopic Diagnostic Indices and Hematologic Ratios

Time frame: 45 days

Evaluating the role of diagnostic indices (Ulcerative Colitis Disease Activity Index (UC-DAI), Simple Clinical Colitis Activity Index (SCCAI), Fecal Calprotectin (FCP) ≥150μg/ml) in active Ulcerative Colitis (UC) and their correlation with novel hematologic inflammatory markers, including Neutrophil-to-Lymphocyte Ratio (NLR), Platelet-to-Lymphocyte Ratio (PLR), Systemic Inflammatory Response Index (SIRI), Systemic Inflammation Index (SII), and the serum C-Reactive Protein (CRP)-to-Albumin Ratio (CAR).

Sponsors and collaborators

Lead sponsor

Benha University

Other

Registry information

Official study title

Composite Inflammatory Parameters Ratios Enforce the Role of CRP for Monitoring Ulcerative Colitis Disease Activity

Important dates

Study start: 2025
Primary completion: 2025
Study completion: 2025
First posted: Dec 3, 2025
Registry last updated: Jan 21, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed