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Completed

NCT Number: NCT06262945

Comperasion the Postoperative Effect of Low Laser Therapy and Platelet Rich Fibrin on Mandibular Third Molar Surgery.

The aim of this study was investigate the comparison of postoperative effects of low laser treatment and platelet-rich fibrin application on mandibular impacted third molar tooth extraction. The study included a total of 60 patients with impacted mandibular third molar. Patients were evaluated in 4 randomly separated groups. In group 1, PRF was applied to the tooth socket. In group 2, PRF was applied to the tooth socket combined with Low Laser Treatment extraorally to the extraction area for three days within surgery day In group 3, Low Laser Treatment was applied to the extraorally to the extraction area for three days within surgery day. In group 4 (control group), tradional osteomy was made. The outcome variables were pain, swelling, the number of analgesics taken, and trismus. These variables were also assessed based on first, second, third, and seventh days following the operation. All of the 4 groups patients were prescribed an 875/125 mg amoxicillin/clavulanic acid tablet twice daily for five days.

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Key information

Conditions

Impacted Third Molar Tooth

Sex eligibility

All sexes

Study type

Observational

Primary location

Near East University

Nicosia, Lefkosa, 99138, Cyprus

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • The patient had no systemic diseases, no taken opioids for a long period, no current infections or acute pericoronitis, no smoke or drink alcohol, no pregnancy, the absence of allergy to penicillin and presence of penicillin allergy.

Exclusion criteria

  • pericoronitis, no inflammation

Treatment and study plan

Diagnoses

Diagnostic Test

All of the patients withstand a radiological examination, including panoramic radiography, and all were handled by the same surgeon and assistant.

traditional osteotomies

Procedure

In all groups the flap incision was triangular in shape which avoids muscle involvement (Archer flap).

Platelet rich fibrin

Biological

Platelet rich fibrin (PRF), is an example and popular procedure for accelerate healing of soft and hard tissue because of the presence of various growth factors.a blood sample was taken without anticoagulant in 10 mL glass-coated plastic tubes that were immediately centrifuged (Elektro-mag M415P) at 3,000 rpm for 10 min (approximately 400 g) (13). The platelet-poor plasma that accumulated at the top of the tubes was discarded.PRF was dissected approximately 2 mm below its contact point with the red corpuscles situated beneath, to include any remaining platelets that may have localized below the junction between the PRF and red corpuscles.

Antibiotics, Penicillin

Drug

Antibiotics are prescribed for the patients.

low laser therapy, bicure laser

Device

There are studies in the literature that low-energy lasers have positive effects on the biological and biochemical processes of wound healing. Acceleration of local circulation, increase in cell proliferation and collagen synthesis are among the various effects of laser application. B Cure Dental Pro Laser application will be applied to the patient for the first 3 days. Low dose laser application will be applied to the angulus area, covering the surgical area for 8 minutes. Before this laser procedure, the patient will be asked to fill out a pain scale. This pain scale and the number of analgesics used will be monitored for 3 days.

Analgesic

Drug

Analgesics are prescribed for the patients.

Primary outcomes

  1. Visual analogue scale (VAS)

    Time frame: Day 1

    It is a measurement instrument for subjective characteristics or attitudes that cannot be directly measured.

  2. Visual analogue scale (VAS)

    Time frame: Day 2

    It is a measurement instrument for subjective characteristics or attitudes that cannot be directly measured.

  3. Visual analogue scale (VAS)

    Time frame: Day 3

    It is a measurement instrument for subjective characteristics or attitudes that cannot be directly measured.

  4. Visual analogue scale (VAS)

    Time frame: Day 7

    It is a measurement instrument for subjective characteristics or attitudes that cannot be directly measured.

  5. Trismus

    Time frame: Day 1

    Trismus by measuring the distance between the mesial incisal corners of the upper and lower right incisors during maximum mouth opening.

  6. Trismus

    Time frame: Day 2

    Trismus by measuring the distance between the mesial incisal corners of the upper and lower right incisors during maximum mouth opening.

  7. Trismus

    Time frame: Day 3

    Trismus by measuring the distance between the mesial incisal corners of the upper and lower right incisors during maximum mouth opening.

  8. Trismus

    Time frame: Day 7

    Trismus by measuring the distance between the mesial incisal corners of the upper and lower right incisors during maximum mouth opening.

  9. Swelling

    Time frame: Day 1

    measured using a flexible plastic measuring tape as described by Gabka and Matsumura by measuring the distance from the corner of the mouth to the attachment of the earlobe following the bulge of the cheek and the distance from the outer canthus of the eye to the angle of the mandible.

  10. Swelling

    Time frame: Day 2

    measured using a flexible plastic measuring tape as described by Gabka and Matsumura by measuring the distance from the corner of the mouth to the attachment of the earlobe following the bulge of the cheek and the distance from the outer canthus of the eye to the angle of the mandible.

  11. Swelling

    Time frame: Day 3

    measured using a flexible plastic measuring tape as described by Gabka and Matsumura by measuring the distance from the corner of the mouth to the attachment of the earlobe following the bulge of the cheek and the distance from the outer canthus of the eye to the angle of the mandible.

  12. Swelling

    Time frame: Day 7

    measured using a flexible plastic measuring tape as described by Gabka and Matsumura by measuring the distance from the corner of the mouth to the attachment of the earlobe following the bulge of the cheek and the distance from the outer canthus of the eye to the angle of the mandible.

Secondary outcomes

  1. the number of analgesic tablets

    Time frame: Day 1

  2. the number of analgesic tablets

    Time frame: Day 2

  3. the number of analgesic tablets

    Time frame: Day 3

  4. the number of analgesic tablets

    Time frame: Day 7

Sponsors and collaborators

Lead sponsor

Beste Erismen

Other

Registry information

Official study title

Comparative Examination of the Postoperative Effects of Low-laser Treatment and Platelet-rich Fibrin Applications After Mandibular Impacted Wisdom Teeth Extraction

Important dates

Study start
2024
Primary completion
2024
Study completion
2024
First posted
Feb 16, 2024
Registry last updated
Feb 16, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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