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Completed

NCT Number: NCT06325085

Compensatory and Restorative Rehabilitation Techniques in Stroke

The aim of this randomized controlled trial is to find the combined effects of restorative and compensatory cognitive rehabilitation techniques in mild cognitive impairment after stroke.

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Key information

Age range

50 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Shafi Hospital Dina

Dina, Punjab Province, Pakistan

About this study

Stroke is a prevalent medical neurological condition that often results in cognitive impairments, particularly in the domain of executive functions. Cognitive impairment has a significant impact on executive function in stroke subjects. Cognitive impairment on the stroke survivor exist on any single domain such as attention, spatial ability, language and executive ability more frequently than the multiple domains.

Cognitive training has been shown to be beneficial for rehabilitation of patients with cognitive impairment, but the underlying mechanisms remain unclear.

The combination of restorative and compensatory rehabilitation techniques is beneficial for gaining control over cognitive rehabilitation techniques will improve executive functions. The retention effects evaluated additionally will add a broad insight in this regard. It will improve the learning power of brain through neural plasticity. This leads to restoration of everyday functioning. This study aims to investigate the effects of two distinct rehabilitation approaches on the executive functions of stroke survivors with MCI. Understanding how these rehabilitation strategies impact cognitive recovery is essential for individuals living with post-stroke cognitive impairments.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age between 50 and 70 years
  • Both Genders
  • Individuals diagnosed with stroke 6 months before enrollment
  • Minimum 6 years of schooling
  • Patients with mild cognitive impairment (score 18-25 on MOCA)
  • Individuals able to maintain sitting and standing balance (score 41 on berg balance scale)

Exclusion criteria

  • >10 on post stroke depression rating scale (PSDRS)
  • Spasticity (>3 on Ashworth scale)
  • Other psychological disorders
  • Patients diagnosed with Alzheimer's and dementia

Treatment and study plan

compensatory and restorative rehabilitation techniques

Other

compensatory and restorative rehabilitation techniques Frequency: 10 reps 2-3 times/week for 3 consecutive weeks then evaluation of the effects.

Continue the same techniques for 3 more weeks and then evaluate the retention effects of restorative and compensatory rehabilitation techniques will be evaluated by 9th week.

Traditional cognitive rehabilitation training

Other

Naming words ( ask patient to name food, states, family members) Counting numbers backwards, backward counting of days and months) Spell the word backwards, remembering a piece of information Frequency: 10 reps 2-3 times/week for 3 consecutive weeks then evaluation of the effects.

Continue the same techniques for 3 more weeks and then evaluate the retention effects of restorative and compensatory rehabilitation techniques will be evaluated by 9th week.

Primary outcomes

  1. Montreal cognitive assessment test (Urdu version)

    Time frame: 6 weeks

    MOCA assesses different cognitive domains: attention and concentration, executive functions, memory, language, visuo-constructional skills, conceptual thinking and orientation. The test is one page,30 point test that can be administered in 10 minutes. MOCA is scored by obtaining an item total and the author recommend a clinical cutoff score of 26.is a Patient-completed, condition-specific functional status questionnaire with 10 items including pain, personal care, lifting, reading, headaches, concentration, work, driving, sleeping and recreation.

  2. Cognitive assessment scale for stroke patients (CASP)

    Time frame: 6 weeks

    Its a rapid test for screening post stroke cognitive impairment. It can be performed at the patient bedside by a non expert examiner. A CASP score of 35/36 should alert to possible presence of cognitive impairment. Score can help predict medium level cognitive impairment.

Secondary outcomes

  1. Stroke specific quality of life questionnaire (Urdu version)

    Time frame: 6 weeks

    The SS-QOL questionnaire assesses health related quality of life specific to stroke survivors covering almost 12 domains

  2. Modified Rankin Scale (MRS)

    Time frame: 6 weeks

    It measures degree of disability or dependence in daily activities of people who have suffered stroke or other neurological disability. It is one of the most widely used clinical patients are graded

Sponsors and collaborators

Lead sponsor

Riphah International University

Other

Registry information

Official study title

Combined Effects of Restorative and Compensatory Rehabilitation Techniques on Executive Functions in Stroke With Mild Cognitive Impairment

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Mar 22, 2024
Registry last updated
Sep 3, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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