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NCT Number: NCT07069660

Compass 3: A Novel Transition Program to Reduce Disability After Stroke

This study evaluates a program designed to help individuals transition from inpatient rehabilitation to home following an ischemic or hemorrhagic stroke. Half of the participants will receive a stroke education program while the other half will receive an environmental modifications program.

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Key information

Conditions

Stroke Brain Diseases Cardiovascular Diseases Central Nervous System Diseases Cerebrovascular Disorders Nervous System Diseases Vascular Diseases

Age range

55 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Missouri, Columbia, Missouri, United States

Loading trial locations.

About this study

A gap in care exists at the point of transition from inpatient rehabilitation (IR) to home, when survivors encounter new environmental barriers due to the cognitive and sensorimotor sequelae of stroke. Resolving these barriers and improving independence in the community have potential to significantly improve stroke survivors' long-term morbidity.

Investigators will conduct a randomized, controlled multi-center trial (RCT) and concurrent implementation evaluation and review of process data to examine therapeutic efficacy, cost-effectiveness and implementation potential of a compensatory intervention (COMPASS) designed to improve daily activity performance and participation outcomes in persons transitioning home from inpatient rehabilitation (IR) following a stroke.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Aged ≥55 years at the time of screening
  • Acute stroke diagnosis (IS or ICH) verified by the stroke team or medical record
  • Independent in activities of daily living (ADLs) prior to stroke (premorbid Modified Rankin Scale score ≤2)
  • Plan to discharge to home from an IR
  • Capable of giving informed consent which includes compliance with the requirements and duration of participation as listed in the Informed Consent Form (ICF).

Exclusion criteria

  • Life expectancy <6 months
  • Cognitive impairment that the participant's stroke team or a research team member believes impairs their ability to provide informed consent or make reasoned choice including the interpretation of the self-rated scales
  • Any communication problem that would prevent study completion
  • Residence in a congregate living facility
  • Not eligible for a therapeutic pass
  • Residence outside of the designated catchment area (specific catchment distance to be determined by each site)
  • Site investigator's judgment that the participant would not be able to complete research procedures or interventions
  • Participation in another research study that in the site investigator's judgment could interfere or conflict with this research study's assessments or interventions

Treatment and study plan

COMPASS

Behavioral

The data from the baseline assessment will be used to develop an environmental modification intervention plan. Environmental modifications will be installed before discharge if possible. Problem areas addressed are participant specific (tailored), but the process to identify and address the target area is systematic. All participants will receive identical intervention components. The standardized components include assessment, identification of problematic activities (and environmental barriers), identification of solutions for each problem, implementation of solution set selected by the participant, training, and active practice of daily activities in one's own home and community.

Education program

Behavioral

The control group will experience the same effects of time and attention in the home but no effect on the outcome of interest.

Primary outcomes

  1. Admission to SNF (skilled nursing facility)

    Time frame: From enrollment to 12 months post-discharge from inpatient rehabilitation facility

    Date and days of admission to a skilled nursing facility

Study contacts

Contact information is provided by the study sponsor or research team.

Brianna Holden, OTR/L

CONTACT

[email protected]

(314)935-2501

Susan Stark, PhD

CONTACT

[email protected]

(314)935-2551

Sponsors and collaborators

Lead sponsor

Washington University School of Medicine

Other

Collaborators

  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Registry information

Official study title

Compass 3: A Novel Transition Program to Reduce Disability After a Stroke

Acronym: COMPASS 3

Important dates

Study start
2025
Primary completion
2030
Study completion
2030
First posted
Jul 17, 2025
Registry last updated
Feb 13, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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