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Completed

NCT Number: NCT01508143

Comparitive Study of Two Misoprostol Regimen in Early Pregnancy Termination

The aim of this study is to compare two misoprostol regimen in pregnancy termination.

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Key information

Conditions

Termination

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Hormozgan University of Medical Sciences

Bandar Abbas, Hormozgan, 097145-3388, Iran

About this study

Studies on determining the optimal dosage for misoprostol in pregnancy termination are continuing and still there is no evidence for ideal misoprostol regimen for pregnancy termination. The aim of this study is to compare two misoprostol regimen in pregnancy termination.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • All women who were candidates for early pregnancy termination because of fetal death or other medical conditions
  • Before 14th week of gestation calculated according LMP or first trimester sonography

Exclusion criteria

  • Chorioamnionitis
  • Hypersensitivity to prosstaglandins
  • Past medical history of cardiovascular, kidney or liver or lung diseases
  • Positive history for uterus pathologies
  • suspicious to extra-uterus pregnancy
  • sign and symptoms of uterus infection
  • Molar pregnancy

Treatment and study plan

Misoprostol 400 micrograms

Drug

Misoprostol 400 micrograms each 6 hours for 8 dose

Other names: Cytotec

Misoprostol 800 micrograms

Drug

Misoprostol 800 micrograms each 12 hours for 4 doses

Other names: Cytotec

Primary outcomes

  1. Abortion

    Time frame: 48 hours after treatment

    After 48 hours after treatment each patient is assessed for abortion. Patients are devided into three groups including complete, partial or no abortion.

Secondary outcomes

  1. Duration of abortion

    Time frame: Form the begining of treatment to complete abortion

    Duration of abortion Form the begining of treatment to complete abortion

  2. Adverse Effects

    Time frame: 48 hours after treatment

    including nausea, vomiting, fever and chill, diarhea, abdominal cramp, skin rash

  3. Need for surgery

    Time frame: 48 hours after treatment

    Dilatation & cartage

Sponsors and collaborators

Lead sponsor

Hormozgan University of Medical Sciences

Other

Registry information

Official study title

A Comparative Study of Vaginal Misoprostol Two Dosing Regimen for First Trimester Pregnancy Termination in Patients Admitted at Bandarabbas in Shariati Hospital in 2009

Important dates

Study start
2012
Primary completion
2012
Study completion
2012
First posted
Jan 11, 2012
Registry last updated
Oct 2, 2012

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.