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Completed

NCT Number: NCT07426393

Comparisons of Efficacy of Triphala and Chlorhexidine Mouthwash Against Plaque Accumulation and Gingivitis.

Gingivitis is one of the commonly prevalent oral diseases worldwide which is caused by the bacterial biofilm adhering to the teeth surfaces. Chlorhexidine is the antimicrobial agent most familiar to dental professionals. The need for frequent application of Chlorhexidine and other side effects such as unpleasant taste and staining has stimulated the search for alternatives. "Triphala" is among the most common formulas used in Traditional Ayurvedic Medicine. Triphala has an antibacterial effect. In this context, a study was undertaken to ascertain the effects of a mouthwash prepared with Triphala on the oral health status and compare it with commercially available Chlorhexidine mouthwash.

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Key information

Age range

18 year–45 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Bangladesh Medical University

Dhaka, Bangladesh

About this study

Dental plaque is the main cause of gingivitis and effective plaque control is essential for maintaining gingival health. Along with mechanical cleaning methods, mouthwashes are commonly used as adjunct therapy to reduce plaque accumulation and gingival inflammation. Chlorhexidine is considered the gold standard chemical plaque control agent but its long-term use is limited by side effects such as tooth staining and taste alteration. Triphala, a herbal formulation with known antimicrobial and anti-inflammatory properties has emerged as a potential alternative. Comparing the efficacy of triphala and chlorhexidine mouthwash against plaque accumulation and gingivitis may help to identify a safer and acceptable option for maintaining routine oral hygiene.

Aims and objectives:

To compare the efficacy of triphala and chlorhexidine mouth wash against plaque accumulation and gingivitis.

Materials and methods:

A randomized controlled trial was conducted among 220 patients with chronic generalized gingivitis attending the Outpatient Department of Bangladesh medical University (BMU), Dhaka. Participants were randomly assigned using shuffled numbered cards to Group A (Triphala mouthwash, n = 110) and Group B (Chlorhexidine mouthwash, n = 110).

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age groups of 18-45 years with
  • Mild to moderate gingivitis,
  • Patients with a minimum of 20 teeth, and
  • Patients who have not undergone periodontal treatment in the past 6 months.

Exclusion criteria

  • Use of anti-inflammatory drugs and antibiotics in previous 6 months;
  • Individuals with prosthetic appliances or orthodontic appliances that would interfere with evaluation
  • Allergy to Triphala and Chlorhexidine used in the study;
  • Smokers or users of tobacco in any form
  • Lactating females or pregnant women
  • Mental-retarded patients.

Treatment and study plan

6% Triphala mouthwash

Other

participants received 15 ml of 6% triphala mouthwash twice daily for 30 days

.2% chlorhexidine mouthwash

Other

participants received 15 ml of .2% chlorhexidine mouthwash twice daily for 30 days

Primary outcomes

  1. PIaque Index

    Time frame: 30 days

    plaque index 0:no plaque is in the area adjacent to the gingiva plaque index 1:there is a plaque in the form of a thin film on the gingival margin plaque index 2:there is a visible plaque in the gingival pocket and gingival margin plaque index 3:there is a dense plaque in the gingival pocket and gingival margin

  2. Gingival Index

    Time frame: 30 days

    Gingival index 0: Healthy gums. Gingival index 1: Mild discolouration and oedematous gingiva. No bleeding on probing.

    Gingival index 2: Red, oedematous and shiny gingiva. There is bleeding on probing.

    Gingival index 3: Red, oedematous and ulcerated gingiva. There is spontaneous bleeding.

  3. BIeeding Index

    Time frame: 30 days

Sponsors and collaborators

Lead sponsor

Bangladesh Medical University

Other

Registry information

Official study title

Comparisons of Efficacy of Triphala and Chlorhexidine Mouthwash Against Plaque Accumulation and Gingivitis. A Randomized Controlled Trail.

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Feb 23, 2026
Registry last updated
Feb 23, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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