Comparison the Effects of Dexamethasone and Loteprednol on Epithelial Healing

Corticosteroid has been used for the treatment after phototherapeutic keratectomy (PRK). Dexamethasone, a potent steroid can retard the corneal epithelial healing rate and has numerous serious complications, especially glaucoma. Loteprednol, a new generation of corticosteroid has less potency than dexamethasone and was proposed to has less side effect regarding intraocular pressure (IOP) elevation. Therefore, Investigators would like to compare the effect of dexamethasone and loteprednol on corneal epithelial healing rate after PRK and risk of glaucoma.

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Key information

Conditions

Epithelial Defect After Phototherapeutic Keratectomy

Age range

18 year–40 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Onsiri Thanathanee, Khon Kaen, Changwat Khon Kaen, Thailand

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

the patient with epithelial defect after phototherapeutic keratectomy

Exclusion criteria

the patient with systemic disease such as diabetes and connective tissue disease
the patient with ocular surface disease such as dry eye and recurrent corneal erosion

Treatment and study plan

Dexamethasone

Drug

Loteprednol Etabonate

Drug

Primary outcomes

corneal epithelial healing

Time frame: 1 month

Secondary outcomes

intraocular pressure

Time frame: 6 month

Sponsors and collaborators

Lead sponsor

Khon Kaen University

Other

Registry information

Important dates

Study start: 2012
Primary completion: 2013
Study completion: 2013
First posted: Nov 12, 2012
Registry last updated: Mar 17, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.