Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine
Seoul, 03722, South Korea
Completed
NCT Number: NCT03202953
Comparison of Volume Controlled Ventilation With 1:1 Inspiratory to Expiratory Ratio and Autoflow-volume Controlled Ventilation in Robot-assisted Laparoscopic Radical Prostatectomy With Steep Trendelenburg Position and Pneumoperitoneum
The purpose of this study is to compare the 1: 1 I: E ratio VCV and the autoflow VCV in patients undergoing robot assisted laparoscopic prostatectomy
Completed
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Notify MeKey information
Conditions
Age range
20 year–80 year
Sex eligibility
Male
Study type
Interventional
Phase
Not applicable
Primary location
Who can participate
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
- adult (20-80 years old)
- patients undergoing robot assisted laparoscopic prostatectomy
Exclusion criteria
- history of COPD
- decreased heart function (EF <50%)
- BMI>30
- patients who cannot read the consent form (e.g., blind, foreigner)
Treatment and study plan
ventilation strategy 1
ProcedureIn Group I, after trendelenburg position, patients will be applied 1:1 ratio VCV.
- Tidal volume : 8ml/kg, inspiration:expiration ratio = 1:1, FiO2 = 0.5, maintain end tidal CO2 around 40±5 mmHg. Positive end expiratory pressure will not used.
ventilation strategy 2
ProcedureIn group A, after trendelenburg position, patients will be applied autoflow VCV.
- Tidal volume : 8ml/kg, inspiration:expiration ratio = 1:2, FiO2 = 0.5, maintain end tidal CO2 around 40±5 mmHg. Positive end expiratory pressure will not used.
Primary outcomes
-
PaO2
Time frame: 30 minutes after trendelenburg position
PaO2 analyzed by arterial blood gas analysis
Secondary outcomes
-
PaO2
Time frame: 10 minutes after induction (T1), 30 minutes after trendelenburg position (T2), 60 minutes after trendelenburg position (T3), 10 minutes after supine position (T4)
-
End tidal CO2
Time frame: 10 minutes after induction (T1), 30 minutes after trendelenburg position (T2), 60 minutes after trendelenburg position (T3), 10 minutes after supine position (T4)
-
peak airway pressure
Time frame: 10 minutes after induction (T1), 30 minutes after trendelenburg position (T2), 60 minutes after trendelenburg position (T3), 10 minutes after supine position (T4)
-
blood pressure
Time frame: 10 minutes after induction (T1), 30 minutes after trendelenburg position (T2), 60 minutes after trendelenburg position (T3), 10 minutes after supine position (T4)
-
Arterial blood gas analysis
Time frame: 10 minutes after induction (T1), 30 minutes after trendelenburg position (T2), 60 minutes after trendelenburg position (T3), 10 minutes after supine position (T4)
pH, SaO2, Base excess
Sponsors and collaborators
Lead sponsor
Yonsei University
Other
Registry information
Important dates
- Study start
- 2017
- Primary completion
- 2018
- Study completion
- 2018
- First posted
- Jun 29, 2017
- Registry last updated
- May 18, 2018
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.