Comparison of Two Electroencephalogram (EEG)-Derived Indices With Electroencephalogram Signals

Bispectral Index (BIS) and Entropy indices will be compared with each other, and to raw EEG signals in patients receiving sevoflurane anaesthesia. BIS and Entropy numbers often differ significantly from each other during surgery, and the reason for this has not been studied in detail, therefore remaining only poorly understood. BIS and Entropy, together with multi-channel EEG, will be collected and analyzed later on. Course of anaesthesia and surgery will be annotated. All relevant information from anaesthesia monitor will be collected on computer.

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Key information

Conditions

Anaesthesia Surgery

Age range

50 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Tampere University Hospital

Tampere, 33521, Finland

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Planned surgery necessitating general anaesthesia
Expected duration of anaesthesia 30 min or more
Need of endotracheal intubation
ASA status 1, 2 or 3

Exclusion criteria

Significant disorders of the autonomic or central nervous system
Family history of malignant hyperthermia
Clinical history of anaphylactic reaction against inhaled anaesthetics
Disability to communicate with Finnish language

Treatment and study plan

Primary outcomes

Morphology of electroencephalogram during discrepancy between Entropy and BIS index values

Time frame: 15 minutes

Sponsors and collaborators

Lead sponsor

Arvi Yli-Hankala

Other

Collaborators

Tampere University Hospital

Registry information

Official study title

Comparison of Bispectral Index and Entropy With Electroencephalogram During Sevoflurane Anaesthesia

Important dates

Study start: 2009
Primary completion: 2011
Study completion: 2011
First posted: Mar 1, 2010
Registry last updated: Oct 9, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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