Comparison of Two Dosages of Heparin Before Extracorporeal Circulation

In this study the investigators will study two dosages of heparin before extracorporeal circulation in open chest cardiac surgery.

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Key information

Conditions

Extracorporeal Circulation; Complications

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Clinique Saint-Luc of Bouge

Namur, 5004, Belgium

About this study

In this study the investigators will study two dosages of heparin before extracorporeal circulation in open chest cardiac surgery. The first dosage will be 300 IU per kilogram of REAL weight, the second dosage will be 300 IU per kilogram of IDEAL weight.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

All patients admitted for cardiac open chest surgery

Exclusion criteria

Patient's refusal
Antithrombin III factor < 75%
Patient under treatment by heparin IV

Treatment and study plan

ACT (Activated Clotting Time)

Diagnostic Test

Measure of ACT in the two arms in order to determine if injection of heparin based on ideal weight is better or not than those one on real weight.

Heparin

Drug

300 IU of heparin

Primary outcomes

ACT performance

Time frame: 1 minute

Measure of ACT to be > 400 seconds to allow extracorporeal circulation, but also < 700 seconds to avoid excessive bleeding.

Sponsors and collaborators

Lead sponsor

Astes

Other

Registry information

Important dates

Study start: 2019
Primary completion: 2021
Study completion: 2021
First posted: Nov 26, 2018
Registry last updated: Feb 15, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed