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NCT Number: NCT07420127

Comparison of Two Different Doses of Phenylephrine on Oxytocin Hemodynamic Effect

Cesarean section is one of the commonly performed surgical procedures in the world. Once baby is delivered during the surgical procedure anesthesiologist administer Oxytocin drug through IV cannula which helps the Uterus to contract so that excessive blood loss doesnt occur. But this is associated with fall in blood pressure frequently requiring administration of medications to treat low blood pressure. The most frequently used drug is phenylephrine which can administered along with oxytocin to prevent fall in blood pressure. This study will compare to different doses of Phenylephrine to prevent fall in blood pressure.

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Key information

Conditions

Phenylephrine Cesarean Birth

Age range

20 year–40 year

Sex eligibility

Female

Study type

Interventional

Phase

Phase 4

Primary location

Department of Anesthesia, Holy Family Hospital, Rawalpindi

Rawalpindi, Punjab Province, 46000, Pakistan

Location status: Recruiting

Location contact

Jawad Head of Department of Anesthesia, MBBS, FCPS

CONTACT

[email protected]

+92 333 5428866

About this study

Cesarean section is one of the most commonly performed surgical procedures worldwide. Following delivery of the neonate, oxytocin is routinely administered intravenously to promote uterine contraction and thereby reduce the risk of postpartum hemorrhage. However, oxytocin administration is frequently associated with maternal hypotension, which may necessitate pharmacological intervention. Phenylephrine, a selective α-adrenergic agonist, is commonly used to prevent or treat oxytocin-induced hypotension due to its vasoconstrictive properties. The optimal prophylactic dose of phenylephrine administered concurrently with oxytocin remains uncertain. This study aims to compare two different doses of phenylephrine for the prevention of hypotension following oxytocin administration during cesarean section.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Females having a singleton pregnancy Patients planned for elective cesarean section under spinal anesthesia

Exclusion criteria

  • Patients having a placental abnormality
  • Patients taking beta-blocker and vasodilator therapy
  • Patients with hypertensive disorder

Treatment and study plan

Phenylephrine bolus 75 micrograms

Drug

After delivery of Baby during C section, patient will be administered 3 IU of Oxytocin over 3 minutes along with 75 micrograms of Phenylephrine Intravenously.

Phenylephrine bolus 50 micrograms

Drug

After delivery of Baby during C section, patient will be administered 3 IU of Oxytocin over 3 minutes along with 50 micrograms of Phenylephrine Intravenously.

Primary outcomes

  1. Number of Hypotensive episodes

    Time frame: Number of hypotensive episodes occuring upto 10 minutes after administration of Oxytocin and Phenylephrine

    Hypotension will be defined as fall in Mean Arterial pressure by more than 20% from baseline value.

Secondary outcomes

  1. Rescue Phenylephrine consumed

    Time frame: This will be the total amount of Phenylephrine consumed to treat the hypotensive episodes occuring upto 10 minutes after administration of Oxytocin and Phenylephrine

Study contacts

Contact information is provided by the study sponsor or research team.

Farwa Javed Principal Investigator, MBBS

CONTACT

[email protected]

+92 304 8954091

Sponsors and collaborators

Lead sponsor

Rawalpindi Medical College

Other

Registry information

Official study title

Effects of Two Different Doses of Phenylephrine co Administration on Oxytocin- Induced Hemodynamic Effects

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Feb 19, 2026
Registry last updated
Feb 24, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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