Comparison of Transfers of Thawed Blastocysts Versus Blastocysts Derived From Thawed Bipronuclear Oocytes

Subjects will be randomized to one of two study groups during their cycles of in vitro fertilization (IVF). In one group, the subjects will have all of their embryos cryopreserved at the blastocyst stage, followed by thaw and transfer in a subsequent cycle. In the other group, subjects will have all of their embryos cryopreserved at the bipronuclear oocyte stage, followed by thaw, extended culture, and transfer in a subsequent cycle.

Inclusion criteria

• Female patient seeking autologous in vitro fertilization (IVF) treatment.
• Cycle day 3 serum concentration of follicle stimulating hormone (FSH) less than 10.0 IU/l.
• Baseline total antral follicle count observed on ultrasound with at least eight antral follicles.
• 18 to 40 years of age.
• Ability to read and understand English.

Exclusion criteria

• Embryo biopsy (a.k.a. pre-implantation genetic diagnosis (PGD)).
• Any condition that, in the opinion of the physician or principal investigator, would place the patient at undue risk under this protocol or would otherwise make the protocol inappropriate for that subject.
• No minors will be enrolled in this study.