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NCT Number: NCT07211763

Comparison of Transcutaneous and Arterial Carbon Dioxide Sampling During Jet Ventilation, a Prospective. Study on Patients Undergoing Percutaneous Liver Tumour Radiofrequency Ablation

The study aims to compare the readings from two methods of monitoring carbon dioxide levels during jet ventilation when normal end-tidal monitoring is not possible. During jet ventilation it is technically not possible to monitor the levels of carbon dioxide in exhaled air as is the standard in preoperative care. We will compare transcutaneous (through the skin) monitoring to an arterial blood. sample. Both transcutaneous monitoring and arterial monitoring is currently used as the standard for this patient group at our institution. By collecting data prospectively we can evaluate if there. are discrepancies based on monitoring method. All patients will be treated per standard preoperative protocol and only patients consenting to participate will contribute data to the comparison and statistical analysis.

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Key information

Conditions

Liver Ablation High Frequency Jet Ventilation

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Sahlgrenska University Hospital

Gothenburg, Sweden

Location status: Recruiting

Location contact

Fredrik Olsen, MD PhD

CONTACT

[email protected]

+463134328169

About this study

During percutaneous radio frequency ablation of liver tumours, jet. ventilation is used to minimise diaphragm movement. By not having conventional ventilation the interventional radiologist have better conditions to perform the treatment and minimising risk damaging adjacent tissue. Jet ventilation does however remove the possibility to monitor end tidal CO2, necessitating alternative monitoring to ensure adequate ventilation. At our institution we use transcutaneous and arterial blood gas monitoring. We aim to collect data on both modalities and compare the values using a "repeat measure Bland-Altmann" analysis.

Study participants will be managed as per normal protocol and the only difference to the non-participators will be their contribution of prospective data for later analysis.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • adult patients undergoing percutaneous RF liver tumour ablation requiring jet ventilation

Exclusion criteria

  • disease or condition. not compatible with jet ventilation

Treatment and study plan

No interventions

Other

No intervention, solely data collection

Primary outcomes

  1. Difference in CO2 between TcCO2 and PaCO2

    Time frame: during perioperative management

Study contacts

Contact information is provided by the study sponsor or research team.

Carl Hallgren, MD

CONTACT

[email protected]

+460313430286

Fredrik Olsen, MD PhD

CONTACT

[email protected]

+46 313428169

Sponsors and collaborators

Lead sponsor

Sahlgrenska University Hospital

Other

Registry information

Official study title

Transcutaneous Versus Arterial Carbon Dioxide Monitoring During Jet Ventilation

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Oct 8, 2025
Registry last updated
Oct 8, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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