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NCT Number: NCT07750418

Comparison of TLIP Block and QIP Block for Postoperative Analgesia After Lumbar Spine Surgery

This study compares two regional anesthesia techniques used for pain control after lumbar spine surgery: the classic thoracolumbar interfascial plane (TLIP) block and the quadratus lumborum-iliac plane (QIP) block. Patients between 18 and 65 years of age who undergo elective lumbar discectomy (up to two spinal levels) will be observed based on which block their treating anesthesiologist chooses to use as part of routine clinical practice. No randomization or additional intervention beyond standard care will be performed. Researchers will record the total amount of opioid pain medication used in the first 24 hours after surgery, the time until the first request for pain medication, pain scores at several time points after surgery (0, 1, 2, 4, 8, 12, and 24 hours), and any side effects (such as nausea, vomiting, or sedation) or complications related to the block. The aim is to compare the effectiveness and safety of these two techniques in reducing pain and opioid use after lumbar spine surgery.

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Key information

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Vezirköprü State Hospital

Vezirköprü, Samsun, Turkey (Türkiye)

Location contact

BETUL MALKOC, MD

SUB_INVESTIGATOR

BETUL YILMAZ, MD

CONTACT

[email protected]

+90 505 035 64 70

BETUL YILMAZ, MD

SUB_INVESTIGATOR

EMINE OZDEMIR, MD

SUB_INVESTIGATOR

MEHMET YUSUF YILMAZ, MD

CONTACT

[email protected]

+90 537 816 24 87

MEHMET YUSUF YILMAZ, MD

PRINCIPAL_INVESTIGATOR

OZGUR DOKMECI, MD

SUB_INVESTIGATOR

About this study

Patients undergoing elective lumbar discectomy at up to two levels, ASA physical status I-II, aged 18-65 years, who receive either a classic TLIP block or a QIP block as part of routine clinical anesthesia practice will be included in this prospective observational study. The choice of block technique is determined solely by the treating anesthesiologist's routine practice, not by study allocation. Both blocks are performed under ultrasound guidance at the end of surgery, before emergence from anesthesia, using bilateral injections of 20 mL (40 mL total) of 0.25% bupivacaine. All patients receive standardized general anesthesia and a multimodal analgesic regimen (intravenous paracetamol, dexketoprofen, and tramadol as rescue analgesia for VAS ≥ 4). Outcomes recorded include total opioid consumption in the first 24 postoperative hours, time to first opioid request, VAS pain scores at PACU (0h), 1, 2, 4, 8, 12, and 24 hours, postoperative side effects (nausea, vomiting, pruritus, sedation, hypotension), and block-related complications (hematoma, local anesthetic systemic toxicity, infection).

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Aged 18-65 years
  • ASA physical status I-II
  • Undergoing elective lumbar discectomy at up to two spinal levels under general anesthesia
  • Receiving classic TLIP block or QIP block for postoperative analgesia as part of routine clinical practice

Exclusion criteria

  • Hypersensitivity or allergy to study medications
  • Coagulopathy
  • Infection at the injection site
  • Severe neurological deficit
  • Chronic opioid use
  • Advanced hepatic or renal failure
  • Obesity (BMI >35 kg/m2)
  • Pregnancy
  • ASA physical status III-IV
  • Mental retardation
  • Inability to provide informed consent

Treatment and study plan

Thoracolumbar Interfascial Plane (TLIP) Block of bupivacaine

Procedure

Ultrasound-guided injection of 20 mL bilaterally (40 mL total) of 0.25% bupivacaine into the fascial plane between the multifidus and longissimus muscles at the relevant lumbar level, performed at the end of surgery before emergence from anesthesia, as part of routine postoperative analgesia.

Other names: TLIP Block

Quadratus Lumborum-Iliac Plane (QIP) Block

Procedure

Ultrasound-guided injection of 20 mL bilaterally (40 mL total) of 0.25% bupivacaine into the interfascial plane between the erector spinae and quadratus lumborum muscles at the iliac crest level, performed at the end of surgery before emergence from anesthesia, as part of routine postoperative analgesia.

Other names: QIP Block

Primary outcomes

  1. Total Opioid Consumption in the First 24 Postoperative Hours

    Time frame: 0 to 24 hours after surgery

    Cumulative amount of intravenous tramadol (mg) administered as rescue analgesia during the first 24 hours after surgery in each group.

Secondary outcomes

  1. Time to First Opioid Request

    Time frame: Up to 24 hours after surgery

    Time elapsed from end of surgery to the first patient request for rescue opioid analgesia (VAS ≥ 4)

  2. Postoperative Pain Score (Visual Analog Scale)

    Time frame: 0, 1, 2, 4, 8, 12, and 24 hours after surgery

    Pain intensity measured using the Visual Analog Scale (VAS, 0 = no pain, 10 = worst imaginable pain) at PACU (0h) and at 1, 2, 4, 8, 12, and 24 hours after surgery.

  3. Incidence of Postoperative Side Effects

    Time frame: Up to 24 hours after surgery

    Number of patients experiencing nausea, vomiting, pruritus, sedation, or hypotension after surgery.

  4. Incidence of Block-Related Complications

    Time frame: Up to 24 hours after surgery

    Number of patients experiencing hematoma, local anesthetic systemic toxicity, or infection related to the block procedure.

Study contacts

Contact information is provided by the study sponsor or research team.

BETUL YILMAZ, MD

CONTACT

[email protected]

+90 505 035 64 70

MEHMET YUSUF YILMAZ, MD

CONTACT

[email protected]

+90 537 816 24 87

Sponsors and collaborators

Lead sponsor

Vezirköprü State Hospital

Other

Registry information

Official study title

Comparison of the Efficacy of Classic Thoracolumbar Interfascial Plane (TLIP) Block and Quadratus Lumborum-Iliac Plane (QIP) Block for Postoperative Analgesia in Patients Undergoing Lumbar Vertebral Surgery: A Prospective Observational Study

Acronym: TLIP-QIP

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Aug 6, 2026
Registry last updated
Aug 6, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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