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Completed

NCT Number: NCT02604082

Comparison of Three Technical Airway Clearance in Mechanical Ventilated Patients

Randomized clinical trial, conducted in the Intensive Care Unit of the Hospital de Clinicas de Porto Alegre from october 2011 until november 2015 .

Completed

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Key information

Conditions

Mucociliary Clearance Defect Physical Disability

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

About this study

Objective: To compare the effectiveness of techniques: vibrocompression (G1), hyperinflation with mechanical ventilation (G2) vibrocompression + hyperinflation with mechanical ventilation (G3) in the amount of aspirated secretions, mechanical ventilator time, incidence of ventilator-associated pneumonia , reintubation tracheal and mortality in mechanical ventilator. Primary outcome: weight in grams of the aspirated secretions. Secondary outcome: hemodynamic and pulmonary parameters: heart rate, respiratory rate, mean arterial pressure, peripheral arterial oxygen saturation; peak inspiratory pressure, tidal volume; dynamic compliance ; mechanical ventilator time; reintubation tracheal; Incidence of ventilator-associated pneumonia and mortality in mechanical ventilator.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • In mechanical ventilation for a period of 24-72 h
  • End-expiratory pressure (PEEP) lower 10 cm of water.
  • Lower noradrenaline doses of 0.5mg / kg / minute for an average greater than or equal blood outstrips 60 mmHg.

Exclusion criteria

  • Pneumothorax and hemothorax undrained
  • Subcutaneous emphysema
  • Osteoporosis
  • Acute respiratory distress syndrome - (ARDS)
  • Fractures of ribs
  • Obese ( BMI greater than 35)
  • Mechanical ventilator with higher peak pressures 40 cm of water.

Treatment and study plan

Vibrocompression (VB)

Other

Vibrocompression is a physical therapy technique, that aims to clear the airways of patients on mechanical ventilation (MV)

Other names: Techinique of physical therapy

Hyperinflation (HMV)

Other

Hyperinflation technique with mechanical ventilator which aims to clear the airways of patients on mechanical ventilation

Other names: Techinique of physical therapy

HMV+VB

Other

Association between Vibrocompression and Hyperinflation with mechanical ventilator

Other names: Techinique of physical therapy

Primary outcomes

  1. Weight in grams of the pulmonary secretions

    Time frame: up to 24 weeks.

Secondary outcomes

  1. Time mechanical ventilator (MV) in days

    Time frame: Through study completion, an average of 3 years.

  2. Reintubation tracheal in percentage in the last 24 hours

    Time frame: Through study completion, an average of 3 years.

  3. Incidence of ventilator-associated pneumonia in percentage

    Time frame: Through study completion, an average of 3 years.

  4. Mortality in the MV in percentage

    Time frame: Through study completion, an average of 3 years.

  5. Heart Rate

    Time frame: up to 24 weeks.

  6. Respiratory frequency

    Time frame: up to 24 weeks

  7. Peripheral oxygen saturation in percentage

    Time frame: up to 24 weeks

  8. Tidal volume in milliliters

    Time frame: up to 24 weeks

  9. Peak inspiratory pressure in centimeters of water

    Time frame: up to 24 weeks

Sponsors and collaborators

Lead sponsor

Hospital de Clinicas de Porto Alegre

Other

Registry information

Acronym: ClearanceMV

Important dates

Study start
2011
Primary completion
2015
Study completion
2015
First posted
Nov 13, 2015
Registry last updated
Nov 13, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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