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Completed

NCT Number: NCT04504643

Comparison of Three Motor-cognitive Training Programs

Understanding how to delay age-related physical and mental declines is an issue for aging research. It has been shown that isolated aerobic, coordination and cognitive training improve brain functions and cognitive performances. Moreover, the combination of them leads to greater effects. Different combination modalities are possible: training programs demanding cognitive resources within the activity performed in a natural environment like Nordic Walking (or Tai chi, Dance...); or as in a conceptually-grounded circuit training where training components are systematically combined and their intensity controlled. The aim of this study is to compare three training programs: a Nordic walking one (NW), and two conceptual grounded, circuits training (CT-c; CT-fit). CT-c implemented by dual-task (DT) exercises, while CT-fit characterized by cognitive charge embodied in the movements through the use of technology. An improvement in physical, motor, and cognitive functions is expected by all three groups. However, our primary hypothesis is that the CT-fit will impact executive functions more.

45 healthy independent living community dwellers participants aged 65 to 80 will be recruited. Participants will be included after a general medical examination (geriatric screening and cycle-ergometer maximal effort test). The main exclusion criteria are signs of cognitive impairment, (MMSE <26/30), and physical impairments. Participants will be randomly divided into the 3 groups (NW, CT-c, CT-fit): The training program will last 8 weeks, 1 hour 3 times a week. Pre and post-tests will include cognitive assessment (MoCA; TMT; Stroop task, Happy Neuron™ working memory test, Rey Complex Figure copy task and dual-task capacities through the DT-OTMT); motor fitness assessment (Bipedal upright standing, Unipedal balance test, walking speed and size of the base of support, Timed Up & Go, Chair sit and reach test and Four square stepping test) and physical assessment (10 m incremental shuttle walking test, maximal handgrip force, 30s chair rise stand).

Improving cognitive functions by adding new technology embodied in a systematically combined training (exergame), would result to be the best solution to optimize training for aging people.

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Key information

Conditions

Cognitive Decline Cognition Disorders Cognitive Dysfunction Mental Disorders Neurocognitive Disorders

Age range

65 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Institut des Sciences du Mouvement Etienne-Jules Marey (UMR 7287)

Marseille, France

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Considered apt for moderate physical activity practice (validated by a maximal VO2 cycle-ergometer test by a cardiologist)
  • Sedentary or moderately active (objectified by the categories obtained at the IPAQ)
  • Cognitively healthy (objectified by a score at the MMSE of 26 and above)

Exclusion criteria

  • Colorblindness
  • Uncorrected earing and/or visual impairment
  • Presence of a known psychiatric or neurologic condition
  • Under psychotropic treatment or beta-blockers

Treatment and study plan

Technology-assisted circuit training

Other

Circuit training assisted by Fitlight™ 3 times a week for one hour during 8 weeks

Conventional circuit training

Other

Conventional circuit training including single and dual task 3 times a week for one hour during 8 weeks

nordic walking

Other

Classic nordic walking 3 times a week for one hour during 8 weeks

Primary outcomes

  1. Changes in working memory function through HappyNeuron Software

    Time frame: Through study completion, an average of 9 months

    Assessment for changing in working memory function tested within the 4 weeks before the intervention (8 weeks of duration) and within the 4 weeks after the intervention ended. Up to 5 months for the results analysis and manuscript writing.

  2. Changes in inhibition processes through Stroop task test

    Time frame: Through study completion, an average of 9 months

    Assessment for changing of inhibition processes tested within the 4 weeks before the intervention (8 weeks of duration) and within the 4 weeks after the intervention ended. Up to 5 months for the results analysis and manuscript writing.

  3. Changes in switching capacities through Trial Making Test part A and part B (TMT-A and TMT-B)

    Time frame: Through study completion, an average of 9 months

    Assessment for changing of switching capacities tested within the 4 weeks before the intervention (8 weeks of duration) and within the 4 weeks after the intervention ended. Up to 5 months for the results analysis and manuscript writing.

  4. Changes in visuospatial capacities through Rey complex Figure copy task

    Time frame: Through study completion, an average of 9 months

    Assessment for changing of visuospatial capacities tested within the 4 weeks before the intervention (8 weeks of duration) and within the 4 weeks after the intervention ended. Up to 5 months for the results analysis and manuscript writing.

  5. Changes in dual task capacities through Walking Oral Trail Making Test part A and part B (OTMT-A and OTMT-B)

    Time frame: Through study completion, an average of 9 months

    Assessment for chainging for dual task capacities tested within the 4 weeks before the intervention (8 weeks of duration) and within the 4 weeks after the intervention ended. Up to 5 months for the results analysis and manuscript writing.

  6. Changes in global cognition capacity through the Moca test

    Time frame: Through study completion, an average of 9 months

    Assessment for changing for general cognition tested within the 4 weeks before the intervention (8 weeks of duration) and within the 4 weeks after the intervention ended. Up to 5 months for the results analysis and manuscript writing.

Secondary outcomes

  1. Changes in balance capacities through Bipedal upright standing and Unipedal leg stance tests

    Time frame: Through study completion, an average of 9 months

    Assessment for balance using a force platform for the bipedal upright standing (AMTI, Advanced Mechanical Technology, Inc., MA, USA). Both assessments tested within the 4 weeks before the intervention (8 weeks of duration) and within the 4 weeks after the intervention ended. Up to 5 months for the results analysis and manuscript writing.

  2. Changes in Gait pattern assessment

    Time frame: Through study completion, an average of 9 months

    Assessment to test gait pattern using a Gait rite (walking at usual speed on a gait rite - GAITRite system, CIR Systems, Havertown, PA, United States) tested within the 4 weeks before the intervention (8 weeks of duration) and within the 4 weeks after the intervention ended. Up to 5 months for the results analysis and manuscript writing.

  3. Changes in functional mobility through the Timed Up & Go test

    Time frame: Through study completion, an average of 9 months

    Assessment for functional mobility tested within the 4 weeks before the intervention (8 weeks of duration) and within the 4 weeks after the intervention ended. Up to 5 months for the results analysis and manuscript writing.

  4. Changes for flexibility through the Chair-sit and reach test

    Time frame: Through study completion, an average of 9 months

    Assessment for functional flexibility tested within the 4 weeks before the intervention (8 weeks of duration) and within the 4 weeks after the intervention ended. Up to 5 months for the results analysis and manuscript writing.

  5. Changes in motor coordination through the Four- Square Stepping test

    Time frame: Through study completion, an average of 9 months

    Assessment for functional motor coordination tested within the 4 weeks before the intervention (8 weeks of duration) and within the 4 weeks after the intervention ended. Up to 5 months for the results analysis and manuscript writing.

  6. Changes in muscular strength through Maximal handgrip force test

    Time frame: Through study completion, an average of 9 months

    Assessment for muscular strength (using JAMAR® hand dynamometer) tested within the 4 weeks before the intervention (8 weeks of duration) and within the 4 weeks after the intervention ended. Up to 5 months for the results analysis and manuscript writing.

  7. Changes in cardiovascular capacities through Shuttle walk test

    Time frame: Through study completion, an average of 9 months

    Assessment for cardiovascular capacities tested within the 4 weeks before the intervention (8 weeks of duration) and within the 4 weeks after the intervention ended. Up to 5 months for the results analysis and manuscript writing.

Sponsors and collaborators

Lead sponsor

Aix Marseille Université

Other

Registry information

Official study title

Physical - Cognitive Training Programs in Older Adults: A Comparison of Three Training Protocols

Acronym: EXECO

Important dates

Study start
2022
Primary completion
2023
Study completion
2023
First posted
Aug 7, 2020
Registry last updated
Feb 16, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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