Comparison of the QT/QTc Interval Between an Outpatient HIV-Infected Population on Antiretroviral Therapy and Two Large HIV-Negative Cohorts

Primary objective:

The primary objective is to compare the QT/QTc intervals of HIV positive subjects treated with antiretroviral therapy and followed at the ambulatory HIV clinic and the QT/QTc intervals of :

• an outpatient HIV negative population from the same health center pre-admission one-day surgical clinic.
• the large HIV-free korean population studied in the ECG-ViEW database.

Secondary objectives :

• Evaluate the prevalence of QTc interval prolongation in the outpatient HIV positive population comparatively to the two HIV negative outpatient populations available from the one-day surgical clinic and the ECG-ViEW database.
• Evaluate risk factors associated with QTc interval prolongation in the outpatient HIV positive population compared to the outpatient HIV negative population and the population studied in the ECG-ViEW database.
• Compare the QT/QTc intervals and the prevalence of QTc interval prolongation of the outpatient HIV positive population currently on an antiretroviral regimen including a protease inhibitor versus those on an antiretroviral regimen without protease inhibitor.
• Compare the QT/QTc intervals among the outpatient HIV positive population treated with a protease inhibitor, in regard to the presence or the absence of certain genetic polymorphisms that may influence pharmacokinetic aspects of protease inhibitors.

Inclusion criteria

• Age eligible for study : 18-65 years old inclusively
• Gender eligible for study : Both

Exclusion criteria

• Hospitalised at the moment of recruitment
• AIDS status

o Opportunistic infections acquired in the last 30 days before the date of recruitment

• Age < 18 years old and > 65 years old
• Follow-up care in an oncology clinic
• Dialysis during the study period
• Pregnancy
• Without antiretroviral therapy
• History of a myocardial infarction in the 3 weeks preceding recruitment
• Have a pacemaker
• Diagnosed with bundle branch block on ECG
• Principal follow-up care outside of the CHUM HIV clinic
• Refusal to participate in the study