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NCT Number: NCT07123740

Comparison of the Postoperative Analgesic Effects of ITM and Bi-level ESPB in Liver Transplantation Donors

Liver transplantation is a life-saving procedure for patients with end-stage liver disease, and postoperative pain management is critical for optimizing donor recovery and overall outcomes. Poorly controlled pain following donor hepatectomy may reduce quality of life, delay mobilization, and contribute to the development of chronic pain syndromes.

Regional anesthesia techniques, such as intrathecal morphine and erector spinae plane block, have been utilized to enhance postoperative analgesia and reduce perioperative opioid requirements, potentially minimizing opioid-related adverse effects.

In this study, we aimed to compare the postoperative analgesic efficacy of intrathecal morphine and Bi-level erector spinae plane block in living liver donors.

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Key information

Conditions

Liver Transplantation Agnosia Nervous System Diseases Neurobehavioral Manifestations Neurologic Manifestations Pain Management Pathological Conditions, Signs and Symptoms Perceptual Disorders Signs and Symptoms

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients aged 18-65 years
  • American Society of Anesthesiologists (ASA) score I-II
  • Body Mass Index (BMI) between 18-30 kg/m2

Exclusion criteria

  • Patients under 18 and over 65 years of age
  • ASA score III and above
  • Patients with a history of bleeding diathesis
  • BMI below 18 or above 30 kg/m2

Treatment and study plan

Intrathecal Morphine

Procedure

An intrathecal injection of morphine 300μg will be administered at the L3-L4 or L4-L5 level.

Additionally, in the postoperative period a dexketoprofen dose of 50 mg twice daily were administered iv for multimodal analgesia.

Bi-level Erector Spinae Plane Block

Procedure

Bi-level erector spinae plane block will be performed on the patients using a total of 40 ml of 0.25% bupivacaine under ultrasound guidance.

Additionally, in the postoperative period a dexketoprofen dose of 50 mg twice daily were administered iv for multimodal analgesia.

Primary outcomes

  1. Pain Scores

    Time frame: On the operation day

    Pain will be assessed at rest and while coughing using the visual analog scale on a scale from 0 (no pain) to 10 (worst pain). Pain assessment will be done at 0st, 1st, 2nd,4th, 12th, and 24th hours after surgery.

Secondary outcomes

  1. Intraoperative opioid consumption

    Time frame: Intraoperative period

    Remifentanil consumption for intraoperative period will be recorded

  2. Postoperative Opioid Consumption

    Time frame: On the operation day

    Opioid consumption for 24 hours will be recorded

Study contacts

Contact information is provided by the study sponsor or research team.

Atakan Sezgi

CONTACT

[email protected]

00905323327000

Jülide Ergil

CONTACT

[email protected]

00905323469216

Sponsors and collaborators

Lead sponsor

Ankara Etlik City Hospital

Other Gov

Registry information

Official study title

Comparison of the Postoperative Analgesic Effects of Intrathecal Morphine and Bi-level Erector Spinae Plane Block in Liver Transplantation Donors

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Aug 14, 2025
Registry last updated
Aug 19, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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